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Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief
DC Field | Value | Language |
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dc.contributor.author | 신동아 | - |
dc.contributor.author | 하윤 | - |
dc.contributor.author | 이혜영 | - |
dc.contributor.author | 이혜란 | - |
dc.date.accessioned | 2023-10-19T05:46:48Z | - |
dc.date.available | 2023-10-19T05:46:48Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196272 | - |
dc.description.abstract | This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | HyeYeong Lee | - |
dc.contributor.googleauthor | GiYoong Tae | - |
dc.contributor.googleauthor | SaeYeon Hwang | - |
dc.contributor.googleauthor | SungWon Wee | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Hye-Lan Lee | - |
dc.contributor.googleauthor | DongAh Shin | - |
dc.identifier.doi | 10.3390/biomedicines11051436 | - |
dc.contributor.localId | A02092 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J03914 | - |
dc.identifier.eissn | 2227-9059 | - |
dc.identifier.pmid | 37239107 | - |
dc.subject.keyword | adipose-derived stem cell | - |
dc.subject.keyword | hydrogel | - |
dc.subject.keyword | micropatch | - |
dc.subject.keyword | neuropathic pain | - |
dc.subject.keyword | neuroregeneration | - |
dc.contributor.alternativeName | Shin, Dong A | - |
dc.contributor.affiliatedAuthor | 신동아 | - |
dc.contributor.affiliatedAuthor | 하윤 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1436 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, Vol.11(5) : 1436, 2023-05 | - |
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