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Occipital Amyloid Deposition Is Associated with Rapid Cognitive Decline in the Alzheimer's Disease Continuum
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.date.accessioned | 2023-10-19T05:46:12Z | - |
dc.date.available | 2023-10-19T05:46:12Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196268 | - |
dc.description.abstract | Background: Clinical significance of additional occipital amyloid-β (Aβ) plaques in Alzheimer's disease (AD) remains unclear. Objective: In this study, we investigated the effect of regional Aβ deposition on cognition in patients on the AD continuum, especially in the occipital region. Methods: We retrospectively reviewed the medical record of 208 patients with AD across the cognitive continuum (non-dementia and dementia). Multivariable linear regression analyses were performed to determine the effect of regional Aβ deposition on cognitive function. A linear mixed model was used to assess the effect of regional deposition on longitudinal changes in Mini-Mental State Examination (MMSE) scores. Additionally, the patients were dichotomized according to the occipital-to-global Aβ deposition ratio (ratio ≤1, Aβ-OCC- group; ratio >1, Aβ-OCC+ group), and the same statistical analyses were applied for between-group comparisons. Results: Regional Aβ burden itself was not associated with baseline cognitive function. In terms of Aβ-OCC group effect, the Aβ-OCC+ group exhibited a poorer cognitive performance on language function compared to the Aβ-OCC- group. High Aβ retention in each region was associated with a rapid decline in MMSE scores, only in the dementia subgroup. Additionally, Aβ-OCC+ individuals exhibited a faster annual decline in MMSE scores than Aβ-OCC- individuals in the non-dementia subgroup (β= -0.77, standard error [SE] = 0.31, p = 0.013). Conclusion: The present study demonstrated that additional occipital Aβ deposition was associated with poor baseline language function and rapid cognitive deterioration in patients on the AD continuum. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alzheimer Disease* / complications | - |
dc.subject.MESH | Alzheimer Disease* / psychology | - |
dc.subject.MESH | Amyloid beta-Peptides | - |
dc.subject.MESH | Cognitive Dysfunction* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Positron-Emission Tomography | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Occipital Amyloid Deposition Is Associated with Rapid Cognitive Decline in the Alzheimer's Disease Continuum | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seong Ho Jeong | - |
dc.contributor.googleauthor | Jungho Cha | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.3233/JAD-230187 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J01231 | - |
dc.identifier.eissn | 1875-8908 | - |
dc.identifier.pmid | 37355901 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad230187 | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | amyloid | - |
dc.subject.keyword | cognition | - |
dc.subject.keyword | occipital lobe | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 94 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1133 | - |
dc.citation.endPage | 1144 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, Vol.94(3) : 1133-1144, 2023-08 | - |
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