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Expression of EMP 1, 2, and 3 in Adrenal Cortical Neoplasm and Pheochromocytoma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2023-08-24T06:14:49Z | - |
dc.date.available | 2023-08-24T06:14:49Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196228 | - |
dc.description.abstract | The purpose of this study is to investigate the expression of the epithelial membrane proteins (EMP) 1, 2, and 3 in adrenal gland neoplasm and to explore the broader implications of this. Tissue microarrays were constructed for 132 cases of adrenal cortical neoplasms (ACN) (adrenal cortical adenoma (115 cases), and carcinoma (17 cases)) and 189 cases of pheochromocytoma. Immunohistochemical staining was performed to identify EMP 1, 2, and 3, and was compared with clinicopathological parameters. The H-score of EMP 3 (p < 0.001) was higher in pheochromocytoma when compared to that of ACN, and the H-score of EMP 1 (p < 0.001) and EMP 3 (p < 0.001) was higher in adrenal cortical carcinomas when compared to that of adrenal cortical adenomas. A higher EMP 1 H-score was observed in pheochromocytomas with a GAPP score ≥3 (p = 0.018). In univariate analysis, high levels of EMP 1 and EMP 3 expression in ACN were associated with shorter overall survival (p = 0.001). Differences were observed in the expression of EMPs between ACN and pheochromocytoma. EMPs are associated with malignant tumor biology in adrenal cortical neoplasm and pheochromocytoma, suggesting the role of a prognostic and/or predictive factor for EMPs in adrenal tumor. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Expression of EMP 1, 2, and 3 in Adrenal Cortical Neoplasm and Pheochromocytoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.3390/ijms241613016 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.subject.keyword | adrenal gland tumor | - |
dc.subject.keyword | adrenal cortical neoplasm | - |
dc.subject.keyword | epithelial membrane proteins | - |
dc.subject.keyword | pheochromocytoma | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 13016 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(16) : 13016, 2023-08 | - |
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