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Effect of permissive hypercarbia on lung oxygenation during one-lung ventilation and postoperative pulmonary complications in patients undergoing thoracic surgery: A prospective randomised controlled trial

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dc.contributor.author김남오-
dc.contributor.author오영준-
dc.contributor.author이규호-
dc.contributor.author이창영-
dc.contributor.author조영은-
dc.date.accessioned2023-08-23T00:18:49Z-
dc.date.available2023-08-23T00:18:49Z-
dc.date.issued2023-09-
dc.identifier.issn0265-0215-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196213-
dc.description.abstractBackground: The effect of hypercarbia on lung oxygenation during thoracic surgery remains unclear. Objective: To investigate the effect of hypercarbia on lung oxygenation during one-lung ventilation in patients undergoing thoracic surgery and evaluate the incidence of postoperative pulmonary complications. Design: Prospective randomised controlled trial. Setting: A tertiary university hospital in the Republic of Korea from November 2019 to December 2020. Patients: Two hundred and ninety-seven patients with American Society of Anaesthesiologists physical status II to III, scheduled to undergo elective lung resection surgery. Intervention: Patients were randomly assigned to Group 40, 50, or 60. An autoflow ventilation mode with a lung protective ventilation strategy was applied to all patients. Respiratory rate was adjusted to maintain a partial pressure of arterial carbon dioxide of 40 ± 5 mmHg in Group 40, 50 ± 5 mmHg in Group 50 and 60 ± 5 mmHg in Group 60 during one-lung ventilation and at the end of surgery. Main outcome measures: The primary outcome was the arterial oxygen partial pressure/fractional inspired oxygen ratio after 60 min of one-lung ventilation. Results: Data from 262 patients were analysed. The partial pressure/fractional inspired oxygen ratio was significantly higher in Group 50 and Group 60 than in Group 40 (269.4 vs. 262.9 vs. 214.4; P < 0.001) but was not significantly different between Group 50 and Group 60. The incidence of postoperative pulmonary complications was comparable among the three groups. Conclusion: Permissive hypercarbia improved lung oxygenation during one-lung ventilation without increasing the risk of postoperative pulmonary complications or the length of hospital stay. Trial registration: NCT04175379.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfEUROPEAN JOURNAL OF ANAESTHESIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHHumans-
dc.subject.MESHHypercapnia-
dc.subject.MESHLung / surgery-
dc.subject.MESHOne-Lung Ventilation* / adverse effects-
dc.subject.MESHOxygen-
dc.subject.MESHPostoperative Complications / diagnosis-
dc.subject.MESHPostoperative Complications / epidemiology-
dc.subject.MESHPostoperative Complications / etiology-
dc.subject.MESHProspective Studies-
dc.subject.MESHRespiration, Artificial / adverse effects-
dc.subject.MESHThoracic Surgery*-
dc.subject.MESHTidal Volume-
dc.titleEffect of permissive hypercarbia on lung oxygenation during one-lung ventilation and postoperative pulmonary complications in patients undergoing thoracic surgery: A prospective randomised controlled trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorYoung-Eun Joe-
dc.contributor.googleauthorChang Yeong Lee-
dc.contributor.googleauthorNamo Kim-
dc.contributor.googleauthorKyuho Lee-
dc.contributor.googleauthorSu Jeong Kang-
dc.contributor.googleauthorYoung Jun Oh-
dc.identifier.doi10.1097/eja.0000000000001873-
dc.contributor.localIdA00356-
dc.contributor.localIdA02389-
dc.contributor.localIdA06264-
dc.contributor.localIdA03245-
dc.contributor.localIdA05185-
dc.relation.journalcodeJ00807-
dc.identifier.eissn1365-2346-
dc.identifier.pmid37455644-
dc.identifier.urlhttps://journals.lww.com/ejanaesthesiology/fulltext/2023/09000/effect_of_permissive_hypercarbia_on_lung.10.aspx-
dc.contributor.alternativeNameKim, Namo-
dc.contributor.affiliatedAuthor김남오-
dc.contributor.affiliatedAuthor오영준-
dc.contributor.affiliatedAuthor이규호-
dc.contributor.affiliatedAuthor이창영-
dc.contributor.affiliatedAuthor조영은-
dc.citation.volume40-
dc.citation.number9-
dc.citation.startPage691-
dc.citation.endPage698-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF ANAESTHESIOLOGY, Vol.40(9) : 691-698, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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