Cited 2 times in
Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | 김한상 | - |
dc.date.accessioned | 2023-08-23T00:07:57Z | - |
dc.date.available | 2023-08-23T00:07:57Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196163 | - |
dc.description.abstract | The regulatory effect of non-coding large-scale structural variations (SVs) on proto-oncogene activation remains unclear. This study investigated SV-mediated gene dysregulation by profiling 3D cancer genome maps from 40 patients with colorectal cancer (CRC). We developed a machine learning-based method for spatial characterization of the altered 3D cancer genome. This revealed a frequent establishment of “de novo chromatin contacts” that can span multiple topologically associating domains (TADs) in addition to the canonical TAD fusion/shuffle model. Using this information, we precisely identified super-enhancer (SE)-hijacking and its clonal characteristics. Clonal SE-hijacking genes, such as TOP2B, are recurrently associated with cell-cycle/DNA-processing functions, which can potentially be used as CRC prognostic markers. Oncogene activation and increased drug resistance due to SE-hijacking were validated by reconstructing the patient's SV using CRISPR-Cas9. Collectively, the spatial and clonality-resolved analysis of the 3D cancer genome reveals regulatory principles of large-scale SVs in oncogene activation and their clinical implications. © 2023 The Author(s) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Chromatin | - |
dc.subject.MESH | Colorectal Neoplasms* / genetics | - |
dc.subject.MESH | DNA | - |
dc.subject.MESH | Genome* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prognosis | - |
dc.title | Spatial and clonality-resolved 3D cancer genome alterations reveal enhancer-hijacking as a potential prognostic marker for colorectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyukwang Kim | - |
dc.contributor.googleauthor | Mooyoung Kim | - |
dc.contributor.googleauthor | Andrew J Lee | - |
dc.contributor.googleauthor | Sang-Hyun Song | - |
dc.contributor.googleauthor | Jun-Kyu Kang | - |
dc.contributor.googleauthor | Junghyun Eom | - |
dc.contributor.googleauthor | Gyeong Hoon Kang | - |
dc.contributor.googleauthor | Jeong Mo Bae | - |
dc.contributor.googleauthor | Sunwoo Min | - |
dc.contributor.googleauthor | Yeonsoo Kim | - |
dc.contributor.googleauthor | Yoojoo Lim | - |
dc.contributor.googleauthor | Han Sang Kim | - |
dc.contributor.googleauthor | Young-Joon Kim | - |
dc.contributor.googleauthor | Tae-You Kim | - |
dc.contributor.googleauthor | Inkyung Jung | - |
dc.identifier.doi | 10.1016/j.celrep.2023.112778 | - |
dc.contributor.localId | A01098 | - |
dc.relation.journalcode | J00488 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.pmid | 37453058 | - |
dc.subject.keyword | 3D cancer genome | - |
dc.subject.keyword | CP: Cancer | - |
dc.subject.keyword | CP: Genomics | - |
dc.subject.keyword | clonality | - |
dc.subject.keyword | colorectal cancer | - |
dc.subject.keyword | enhancer-hijacking | - |
dc.subject.keyword | in situ Hi-C | - |
dc.subject.keyword | prognostic marker | - |
dc.subject.keyword | structural variations | - |
dc.contributor.alternativeName | Kim, Han Sang | - |
dc.contributor.affiliatedAuthor | 김한상 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 112778 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, Vol.42(7) : 112778, 2023-07 | - |
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