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Inhibition of PD-L1 and tumor growth in triple-negative breast cancer using a magnetic nanovector with microRNA34a

Authors
 Seung-Hyun Yang  ;  Hye Young Son  ;  Mirae Park  ;  Hyun Wook Rho  ;  Hwunjae Lee  ;  Yong-Min Huh 
Citation
 CANCER NANOTECHNOLOGY, Vol.14(21), 2023-03 
Journal Title
CANCER NANOTECHNOLOGY
ISSN
 1868-6958 
Issue Date
2023-03
Abstract
BackgroundClinical applications of RNA interference for cancer treatment and immune therapy require the development of simultaneous therapy and imaging systems for microRNA. This research was performed to fabricate the miRNA34a-loaded magnetic nanoparticles and investigate its anticancer effects against triple-negative breast cancer (TNBC) in mice model.ResultsUsing two types of polymers to improve their water dispersibility and gene delivery, iron oxide magnetic nanoparticles were prepared for delivery of miRNA34a. The iron oxide magnetic nanoparticles were delivered to TNBC cells, and their efficacy was evaluated in vitro and in vivo. Delivery of miRNA34a reduced TNBC cell migration and decreased the expression of PD-L1 at the mRNA and protein levels. In animal experiments, delivery of miRNA34a reduced tumor growth, and immunostaining and algorithmic analysis confirmed the decrease in PD-L1 expression.ConclusionThis study is the first to modulate PD-L1 by delivering miRNA34a with magnetic nanoparticles, and the results suggest that miRNA34a can be delivered effectively using magnetic nanoparticles and has potential as a molecular imaging contrast agent.
Full Text
https://cancer-nano.biomedcentral.com/articles/10.1186/s12645-023-00171-0
Files in This Item:
T202302522.pdf Download
DOI
10.1186/s12645-023-00171-0
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Yang, Seung Hyun(양승현) ORCID logo https://orcid.org/0000-0002-0909-7828
Lee, Hwun Jae(이훈재)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196121
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