Cited 11 times in
A laboratory association between hemoglobin and VerifyNow P2Y12 reaction unit: A systematic review and meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장양수 | - |
dc.contributor.author | 고영국 | - |
dc.date.accessioned | 2023-08-22T07:17:59Z | - |
dc.date.available | 2023-08-22T07:17:59Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196107 | - |
dc.description.abstract | Background: VerifyNow P2Y12 assay is used widely to evaluate residual platelet reactivity in patients taking P2Y12 receptor antagonists. However, a laboratory association between VerifyNow P2Y12 reaction unit (PRU) and hemoglobin, which might lead to wrong interpretation of the data, is reported. We performed these systematic review and meta-analysis to clearly define the relationship between PRU and hemoglobin and to elucidate whether the relationship, if any, is a true biological association or is just a laboratory error. Methods: Through a comprehensive electronic and manual search, 10 studies were selected for the cohort level meta-analysis. Among 10 studies, we were able to retrieve the raw data of 5 studies, and a patient-level meta-analysis was performed. Potential publication bias was searched by funnel plot analysis and was actively adjusted, if present, by trim and fill method. Results: The pooled analysis revealed a significant inverse correlation between PRU and hemoglobin (r=-0.349; P<.001; 10 studies with 4,793 patients). VerifyNow P2Y12 base unit, which reflects off-drug platelet reactivity, was also inversely correlated with hemoglobin (r=-0.526; P<.001; 8 studies with 4,395 patients). % Inhibition (r=0.081; P=.059; 6 studies with 3,832 patients) and ΔPRU (r=-0.037; P=.188; 5 studies with 3,521 patients) were not associated with hemoglobin. A significant inverse association between PRU and hemoglobin was also observed in the patient-level meta-analysis (3,533 patients pooled from 5 studies; r=-0.335; P<.001). Light transmission aggregometry (r=0.160; P=.072; 4 studies with 1,144 patients) and multiple electrode platelet aggregometry (r=-0.029; P=.394; 3 studies with 7,645 patients) showed no significant association with hemoglobin. Conclusions: A significant inverse association was observed between PRU and hemoglobin which is likely to be a laboratory error. Clinicians should be aware that this association might lead to wrong interpretation of the data. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mosby | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Platelets / drug effects* | - |
dc.subject.MESH | Coronary Artery Disease / blood | - |
dc.subject.MESH | Coronary Artery Disease / drug therapy* | - |
dc.subject.MESH | Hemoglobins / metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Platelet Aggregation / drug effects* | - |
dc.subject.MESH | Platelet Function Tests | - |
dc.subject.MESH | Purinergic P2Y Receptor Antagonists / pharmacology* | - |
dc.title | A laboratory association between hemoglobin and VerifyNow P2Y12 reaction unit: A systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yun Gi Kim | - |
dc.contributor.googleauthor | Jung-Won Suh | - |
dc.contributor.googleauthor | Dirk Sibbing | - |
dc.contributor.googleauthor | Adnan Kastrati | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Young-Seok Cho | - |
dc.contributor.googleauthor | Tae-Jin Youn | - |
dc.contributor.googleauthor | In-Ho Chae | - |
dc.contributor.googleauthor | Dong-Ju Choi | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.identifier.doi | 10.1016/j.ahj.2017.03.006 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A00127 | - |
dc.relation.journalcode | J00069 | - |
dc.identifier.eissn | 1097-6744 | - |
dc.identifier.pmid | 28577681 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S000287031730087X | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.citation.volume | 188 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 64 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, Vol.188 : 53-64, 2017-06 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.