Cited 2 times in
Genomic and transcriptomic profiling reveal molecular characteristics of parathyroid carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김기정 | - |
dc.contributor.author | 김상겸 | - |
dc.contributor.author | 김상우 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 정종주 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2023-08-09T07:02:32Z | - |
dc.date.available | 2023-08-09T07:02:32Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196039 | - |
dc.description.abstract | Genomic and transcriptomic profiling has enhanced the diagnostic and treatment options for many cancers. However, the molecular characteristics of parathyroid cancer remain largely unexplored, thereby limiting the development of new therapeutic interventions. Herein, we conducted genomic and transcriptomic sequencing of 50 parathyroid tissues (12 carcinomas, 28 adenomas, and 10 normal tissues) to investigate the intrinsic and comparative molecular features of parathyroid carcinoma. We confirmed multiple two-hit mutation patterns in cell division cycle 73 (CDC73) that converged to biallelic inactivation, calling into question the presence of a second hit in other genes. In addition, allele-specific repression of CDC73 in copies with germline-truncating variants suggested selective pressure prior to tumorigenesis. Transcriptomic analysis identified upregulation of the expression of E2F targets, KRAS and TNF-alpha signaling, and epithelial-mesenchymal transition pathways in carcinomas compared to adenomas and normal tissues. A molecular classification model based on carcinoma-specific genes clearly separated carcinomas from adenomas and normal tissues, the clinical utility of which was demonstrated in two patients with uncertain malignant potential. A deeper analysis of gene expression and functional prediction suggested that Wilms tumor 1 (WT1) is a potential biomarker for CDC73-mutant parathyroid carcinoma, which was further validated through immunohistochemistry. Overall, our study revealed the genomic and transcriptomic profiles of parathyroid carcinoma and may help direct future precision diagnostic and therapeutic improvements. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenoma* / diagnosis | - |
dc.subject.MESH | Adenoma* / genetics | - |
dc.subject.MESH | Adenoma* / pathology | - |
dc.subject.MESH | Carcinoma* / metabolism | - |
dc.subject.MESH | Genomics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Parathyroid Neoplasms* / diagnosis | - |
dc.subject.MESH | Parathyroid Neoplasms* / genetics | - |
dc.subject.MESH | Parathyroid Neoplasms* / pathology | - |
dc.subject.MESH | Transcriptome | - |
dc.title | Genomic and transcriptomic profiling reveal molecular characteristics of parathyroid carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Se-Young Jo | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Seunghyun Lee | - |
dc.contributor.googleauthor | Jong Ju Jeong | - |
dc.contributor.googleauthor | Jeongsoo Won | - |
dc.contributor.googleauthor | Jiho Park | - |
dc.contributor.googleauthor | Gi Jeong Kim | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.1038/s12276-023-00968-4 | - |
dc.contributor.localId | A06294 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A00524 | - |
dc.contributor.localId | A05934 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03722 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 37121965 | - |
dc.contributor.alternativeName | Kim, Gi Jeong | - |
dc.contributor.affiliatedAuthor | 김기정 | - |
dc.contributor.affiliatedAuthor | 김상겸 | - |
dc.contributor.affiliatedAuthor | 김상우 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 정종주 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 886 | - |
dc.citation.endPage | 897 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.55(5) : 886-897, 2023-05 | - |
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