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CAGE-B and SAGE-B models better predict the hepatitis B virus-related hepatocellular carcinoma after 5-year entecavir treatment than PAGE-B
DC Field | Value | Language |
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dc.contributor.author | 김승업 | - |
dc.contributor.author | 안상훈 | - |
dc.date.accessioned | 2023-08-09T07:01:01Z | - |
dc.date.available | 2023-08-09T07:01:01Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1751-2972 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196031 | - |
dc.description.abstract | Objectives: The PAGE-B model consists of variables at the initiation of antiviral therapy (AVT), whereas the SAGE-B and CAGE-B models consist of variables after 5 years of AVT. We aimed to compare the predictive accuracy of three risk prediction models for hepatocellular carcinoma (HCC) development after 5 years of AVT in patients with chronic hepatitis B (CHB). Methods: A total of 1335 patients who initiated entecavir (ETV) treatment between 2006 and 2011 and were followed up for more than 5 years were enrolled in the study. Results: At ETV initiation, the median age was 49 years and the median score of the PAGE-B model was 14. After 5 years of ETV treatment, the median SAGE-B and CAGE-B scores were 6 and 6. During the study period, 93 (7.0%) patients developed HCC after 5-year treatment. In multivariate analysis, PAGE-B (hazard ratio [HR] 1.151, 95% confidence interval [CI] 1.087-1.219), SAGE-B (HR 1.340, 95% CI 1.228-1.463), and CAGE-B (HR 1.327, 95% CI 1.223-1.440) models independently predicted HCC development after 5 years of treatment (all P < 0.001). The high-risk groups of the three risk prediction models showed a significantly higher risk of HCC development compared to the medium- and low-risk groups (both P < 0.05). The AUROC of the SAGE-B (0.772-0.844) and CAGE-B (0.785-0.838) models was significantly higher than those of the PAGE-B model (0.696-0.745) in predicting HCC development after 5 years of treatment (both P < 0.05). Conclusion: The SAGE-B and CAGE-B models might be better than the PAGE-B model in predicting HCC development after 5 years of ETV treatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Pub. Asia | - |
dc.relation.isPartOf | JOURNAL OF DIGESTIVE DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antiviral Agents / therapeutic use | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / drug therapy | - |
dc.subject.MESH | Hepatitis B virus | - |
dc.subject.MESH | Hepatitis B, Chronic* / drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / drug therapy | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | CAGE-B and SAGE-B models better predict the hepatitis B virus-related hepatocellular carcinoma after 5-year entecavir treatment than PAGE-B | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hye Yeon Chon | - |
dc.contributor.googleauthor | Han Ah Lee | - |
dc.contributor.googleauthor | Soo Young Park | - |
dc.contributor.googleauthor | Yeon Seok Seo | - |
dc.contributor.googleauthor | Sang Gyune Kim | - |
dc.contributor.googleauthor | Chang Hun Lee | - |
dc.contributor.googleauthor | Tae Hee Lee | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Vincent Wai-Sun Wong | - |
dc.contributor.googleauthor | Terry Cheuk-Fung Yip | - |
dc.contributor.googleauthor | Lilian Yan Liang | - |
dc.contributor.googleauthor | In Hee Kim | - |
dc.contributor.googleauthor | Grace Lai-Hung Wong | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.identifier.doi | 10.1111/1751-2980.13172 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A02226 | - |
dc.relation.journalcode | J03012 | - |
dc.identifier.eissn | 1751-2980 | - |
dc.identifier.pmid | 37057685 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/1751-2980.13172 | - |
dc.subject.keyword | CAGE-B | - |
dc.subject.keyword | PAGE-B | - |
dc.subject.keyword | SAGE-B | - |
dc.subject.keyword | hepatitis B | - |
dc.subject.keyword | risk prediction | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 121 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DIGESTIVE DISEASES, Vol.24(2) : 113-121, 2023-02 | - |
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