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Physical Performance Decline During the Early Posttransplantation Period Affects Survival After Living Donor Liver Transplantation

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dc.contributor.author김덕기-
dc.contributor.author김명수-
dc.contributor.author이재근-
dc.contributor.author주동진-
dc.contributor.author주만기-
dc.date.accessioned2023-08-09T06:54:53Z-
dc.date.available2023-08-09T06:54:53Z-
dc.date.issued2023-07-
dc.identifier.issn0041-1337-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196000-
dc.description.abstractBackground: Patient physical performance has been emphasized in liver transplant recipients; however, evidence for living donor liver transplantation (LDLT) patients is lacking. This study investigated the impact of physical performance decline during the early posttransplantation period on survival and risk factors for this decline in LDLT recipients. Methods: From national registry data, 2703 LDLT patients were divided into 2 groups based on the change in their Karnofsky performance status (KPS) between 1 and 6 mo posttransplantation: declined KPS (n = 188) and control (n = 2515). Multivariable analyses were conducted to control for confounders, including posttransplantation complications. Results: Estimated 5-y patient survival rates were 91.6% in the declined KPS group and 96.3% in the control group, favoring the latter ( P = 0.003). The survival hazard of KPS decline was significant in a baseline covariates-adjusted Cox model (hazard ratio [HR], 2.60; 95% confidence interval [CI], 1.37-4.95) and an adjusted model accounting for posttransplantation complications (HR, 3.38; 95% CI, 1.70-6.72). In subgroup analyses, KPS decline independently reduced survival in patients without complications (HR, 3.95; 95% CI, 1.67-9.34), and the trend was similar in patients with complications, although significance was marginal (HR, 3.02; 95% CI, 0.98-9.27). We found that only posttransplantation complications, such as rejection, infection, bile duct complication, and vascular complication, were significant risk factors for KPS decline after LDLT. Conclusions: Physical performance decline during the early posttransplantation period independently reduced survival rates, and posttransplantation complications were the only significant risk factors for physical performance decline in LDLT recipients. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfTRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHLiver Transplantation* / adverse effects-
dc.subject.MESHLiving Donors-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titlePhysical Performance Decline During the Early Posttransplantation Period Affects Survival After Living Donor Liver Transplantation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorDeok-Gie Kim-
dc.contributor.googleauthorShin Hwang-
dc.contributor.googleauthorKwang-Woong Lee-
dc.contributor.googleauthorGyu-Seong Choi-
dc.contributor.googleauthorYoung Kyoung You-
dc.contributor.googleauthorJe Ho Ryu-
dc.contributor.googleauthorBong-Wan Kim-
dc.contributor.googleauthorYang Won Nah-
dc.contributor.googleauthorDong-Sik Kim-
dc.contributor.googleauthorJai Young Cho-
dc.contributor.googleauthorKoo Jeong Kang-
dc.contributor.googleauthorGeun Hong-
dc.contributor.googleauthorHee Chul Yu-
dc.contributor.googleauthorMan Ki Ju-
dc.contributor.googleauthorSuk-Won Suh-
dc.contributor.googleauthorKwan Woo Kim-
dc.contributor.googleauthorDongho Choi-
dc.contributor.googleauthorJaehong Jeong-
dc.contributor.googleauthorSoo Jin Na Choi-
dc.contributor.googleauthorJu Ik Moon-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorDonglak Choi-
dc.contributor.googleauthorDong Jin Joo-
dc.identifier.doi10.1097/tp.0000000000004517-
dc.contributor.localIdA05303-
dc.contributor.localIdA00424-
dc.contributor.localIdA03068-
dc.contributor.localIdA03948-
dc.contributor.localIdA03949-
dc.relation.journalcodeJ02754-
dc.identifier.eissn1534-6080-
dc.identifier.pmid36740738-
dc.identifier.urlhttps://journals.lww.com/transplantjournal/Fulltext/2023/07000/Physical_Performance_Decline_During_the_Early.20-
dc.contributor.alternativeNameKim, Deok Gie-
dc.contributor.affiliatedAuthor김덕기-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor이재근-
dc.contributor.affiliatedAuthor주동진-
dc.contributor.affiliatedAuthor주만기-
dc.citation.volume107-
dc.citation.number7-
dc.citation.startPage1545-
dc.citation.endPage1553-
dc.identifier.bibliographicCitationTRANSPLANTATION, Vol.107(7) : 1545-1553, 2023-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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