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European Committee on Antimicrobial Susceptibility Testing-Recommended Rapid Antimicrobial Susceptibility Testing of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus From Positive Blood Culture Bottles

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dc.contributor.author용동은-
dc.contributor.author이혁민-
dc.contributor.author홍기호-
dc.date.accessioned2023-08-09T06:48:58Z-
dc.date.available2023-08-09T06:48:58Z-
dc.date.issued2023-09-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195969-
dc.description.abstractBackground: Early diagnosis and treatment are important for a good prognosis of bloodstream infections. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommends rapid antimicrobial susceptibility testing (RAST) based on the disk diffusion methodology for 4, 6, and 8 hours of incubation. We evaluated EUCAST-RAST of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus from positive blood culture bottles. Methods: Twenty strains of E. coli, K. pneumoniae, and S. aureus were tested using EUCAST-RAST. Ten antimicrobial agents against E. coli and K. pneumoniae and four agents against S. aureus were tested. The diameter of the inhibition zone (mm) was compared with the minimal inhibitory concentration (μg/mL) obtained using the Sensititre AST system (TREK Diagnostic Systems, East Grinstead, UK). Results: For E. coli, the percentage of total categorical agreement (CA) was 69.5% at 4 hours, and 87% at 8 hours. For K. pneumoniae, the total CA was 89% at 4 hours, and 95.5% at 6 hours. For S. aureus, the total CA was 100% after 4 hours. Discrepancies were observed mainly for E. coli with β-lactam antimicrobial agents, and the numbers of errors decreased over time. Conclusions: EUCAST-RAST for K. pneumoniae and S. aureus met the United States Food and Drug Administration criteria at 6 and 4 hours, respectively, whereas that for E. coli did not meet the criteria for up to 8 hours. RAST can shorten the turn-around testing time by more than one day; therefore, if applied accurately according to laboratory conditions, antimicrobial agent results can be reported faster.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Bacterial Agents / pharmacology-
dc.subject.MESHAnti-Infective Agents*-
dc.subject.MESHBlood Culture-
dc.subject.MESHEscherichia coli-
dc.subject.MESHHumans-
dc.subject.MESHKlebsiella pneumoniae-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHStaphylococcal Infections*-
dc.subject.MESHStaphylococcus aureus-
dc.titleEuropean Committee on Antimicrobial Susceptibility Testing-Recommended Rapid Antimicrobial Susceptibility Testing of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus From Positive Blood Culture Bottles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorJong-Min Park-
dc.contributor.googleauthorMijung Kwon-
dc.contributor.googleauthorKi Ho Hong-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorDongeun Yong-
dc.identifier.doi10.3343/alm.2023.43.5.443-
dc.contributor.localIdA02423-
dc.contributor.localIdA03286-
dc.contributor.localIdA06207-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid37080745-
dc.subject.keywordCategorical agreement-
dc.subject.keywordEscherichia coli-
dc.subject.keywordEuropean Committee on Antimicrobial Susceptibility Testing-
dc.subject.keywordKlebsiella pneumoniae-
dc.subject.keywordMicrobial sensitivity test-
dc.subject.keywordRapid antimicrobial susceptibility testing-
dc.subject.keywordSepsis-
dc.subject.keywordStaphylococcus aureus-
dc.subject.keywordUnited States Food and Drug Administration-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.affiliatedAuthor용동은-
dc.contributor.affiliatedAuthor이혁민-
dc.contributor.affiliatedAuthor홍기호-
dc.citation.volume43-
dc.citation.number5-
dc.citation.startPage443-
dc.citation.endPage450-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.43(5) : 443-450, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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