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Cost-Effectiveness of Age-Expanding Strategy of Latent Tuberculosis Infection Treatment in Household Contacts in South Korea
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 박영목 | - |
dc.date.accessioned | 2023-08-09T06:46:38Z | - |
dc.date.available | 2023-08-09T06:46:38Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195955 | - |
dc.description.abstract | Purpose: The strategy of latent tuberculosis infection (LTBI) treatment in household tuberculosis (TB) contacts has been expanding in South Korea. However, there is little evidence of the cost-effectiveness of LTBI treatment in patients over 35 years of age. This study aimed to evaluate the cost-effectiveness of LTBI treatment among household TB contacts in different age groups in South Korea. Materials and methods: An age-structured model of TB was developed based on the reports from the Korea Disease Control and Prevention Agency and the National Health Insurance Service. Quality-adjusted life-years (QALY) and the averted number of TB-related deaths were estimated along with discounted costs for a measure of incremental cost-effectiveness ratios. Results: The number of cumulative active TB cases would decrease by 1564 and 7450 under the scenario of LTBI treatment for those aged <35 years and <70 years, respectively, relative to the no-treatment scenario. The treatment strategies for patients aged 0 to <35 years, <55 years, <65 years, and <70 years would add 397, 1482, 3782, and 8491 QALYs at a cost of $660, $5930, $4560, and $2530, respectively, per QALY. For the averted TB-related deaths, LTBI treatment targeting those aged 0 to <35 years, <55 years, <65 years, and <70 years would avert 7, 89, 155, and 186 deaths at a cost of $35900, $99200, $111100, and $115700 per deaths, respectively, in 20 years. Conclusion: The age-specific expansion policy of LTBI treatment not only for those under 35 years of age but also for those under 65 years of age among household contacts was cost-effective in terms of QALYs and averted TB deaths. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cost-Benefit Analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Latent Tuberculosis* / drug therapy | - |
dc.subject.MESH | National Health Programs | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Cost-Effectiveness of Age-Expanding Strategy of Latent Tuberculosis Infection Treatment in Household Contacts in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyunwoo Cho | - |
dc.contributor.googleauthor | Jeongjoo Seok | - |
dc.contributor.googleauthor | Youngmok Park | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Eun Hye Lee | - |
dc.contributor.googleauthor | Jungeun Park | - |
dc.contributor.googleauthor | Dong Ah Park | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Jeehyun Lee | - |
dc.identifier.doi | 10.3349/ymj.2022.0624 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A05828 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 37226563 | - |
dc.subject.keyword | Cost-effectiveness analysis | - |
dc.subject.keyword | latent tuberculosis infection | - |
dc.subject.keyword | mathematical model | - |
dc.subject.keyword | tuberculosis | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 박영목 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 366 | - |
dc.citation.endPage | 374 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(6) : 366-374, 2023-06 | - |
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