Cited 8 times in
Higher Serum Levels of Osteoglycin Are Associated with All-Cause Mortality and Cardiovascular and Cerebrovascular Events in Patients with Advanced Chronic Kidney Disease
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.date.accessioned | 2023-08-09T02:52:57Z | - |
dc.date.available | 2023-08-09T02:52:57Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 0040-8727 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195903 | - |
dc.description.abstract | Patients with chronic kidney disease (CKD) have markedly increased rates of major adverse cardiovascular and cerebrovascular events (MACCEs) and mortality. Therefore, identifying early biomarkers predicting clinical outcomes in patients with CKD is critical. We aimed to determine whether osteoglycin, a basic component of the vascular extracellular matrix, was associated with MACCEs or all-cause mortality, using data from a prospective randomized controlled study, K-STAR (Kremezin STudy Against Renal disease progression in Korea: NCT 00860431). A total of 383 patients (mean age: 56.4 years, men/women = 252/131) with CKD stage 3 to 4 from the original trial were enrolled in the present study. We measured serum osteoglycin level and examined the impact of osteoglycin on clinical outcomes. The mean value of osteoglycin levels was 13.3 ± 9.4 ng/mL (healthy control: 5.3 ± 2.1 ng/mL). In multivariable analysis, lower levels of proteinuria and hemoglobin and higher levels of C-reactive protein were significantly associated with higher osteoglycin levels. Estimated glomerular filtration rate was not related to osteoglycin level. During a mean follow-up period of 56 months, 25 deaths, 61 MACCEs, and 76 composite outcomes (all-cause mortality or MACCEs) occurred. In the non-diabetic group, each 1-ng/mL increase in serum osteoglycin was associated with all-cause mortality and composite outcome (hazard ratio [HR] = 1.058, P = 0.031; HR = 1.041, P = 0.036). However, osteoglycin levels were not associated with mortality, MACCEs, or composite outcome in the diabetic group. Our results indicate that serum osteoglycin is a potential predictor of adverse outcomes in patients with CKD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Tohoku University Medical Library | - |
dc.relation.isPartOf | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cardiovascular Diseases / blood* | - |
dc.subject.MESH | Cardiovascular Diseases / complications | - |
dc.subject.MESH | Cardiovascular Diseases / mortality* | - |
dc.subject.MESH | Cerebrovascular Disorders / blood* | - |
dc.subject.MESH | Cerebrovascular Disorders / complications | - |
dc.subject.MESH | Cerebrovascular Disorders / mortality* | - |
dc.subject.MESH | Disease Progression* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intercellular Signaling Peptides and Proteins / blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Renal Insufficiency, Chronic / blood* | - |
dc.subject.MESH | Renal Insufficiency, Chronic / complications | - |
dc.subject.MESH | Renal Insufficiency, Chronic / mortality* | - |
dc.subject.MESH | Renal Insufficiency, Chronic / physiopathology | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Higher Serum Levels of Osteoglycin Are Associated with All-Cause Mortality and Cardiovascular and Cerebrovascular Events in Patients with Advanced Chronic Kidney Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seon Ha Baek | - |
dc.contributor.googleauthor | Ran-Hui Cha | - |
dc.contributor.googleauthor | Shin Wook Kang | - |
dc.contributor.googleauthor | Cheol Whee Park | - |
dc.contributor.googleauthor | Dae Ryong Cha | - |
dc.contributor.googleauthor | Sung Gyun Kim | - |
dc.contributor.googleauthor | Sun Ae Yoon | - |
dc.contributor.googleauthor | Sejoong Kim | - |
dc.contributor.googleauthor | Sang Youb Han | - |
dc.contributor.googleauthor | Jung Hwan Park | - |
dc.contributor.googleauthor | Jae Hyun Chang | - |
dc.contributor.googleauthor | Chun Soo Lim | - |
dc.contributor.googleauthor | Yon Su Kim | - |
dc.contributor.googleauthor | Ki Young Na | - |
dc.identifier.doi | 10.1620/tjem.242.281 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01849 | - |
dc.relation.journalcode | J02738 | - |
dc.identifier.eissn | 1349-3329 | - |
dc.identifier.pmid | 28824047 | - |
dc.subject.keyword | all-cause mortality | - |
dc.subject.keyword | biomarker | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | diabetes mellitus | - |
dc.subject.keyword | osteoglycin | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.citation.volume | 242 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 290 | - |
dc.identifier.bibliographicCitation | TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, Vol.242(4) : 281-290, 2017-08 | - |
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