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Early dialysis initiation does not improve clinical outcomes in elderly end-stage renal disease patients: A multicenter prospective cohort study

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dc.contributor.author강신욱-
dc.date.accessioned2023-08-09T02:49:57Z-
dc.date.available2023-08-09T02:49:57Z-
dc.date.issued2017-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195878-
dc.description.abstractBackground: The optimal timing for initiating dialysis in end-stage renal disease (ESRD) is controversial, especially in the elderly. Methods: 665 patients ≥65 years old who began dialysis from August 2008 to February 2015 were prospectively enrolled in the Clinical Research Center for End-Stage Renal Disease cohort study. Participants were divided into 2 groups based on the median estimated glomerular filtration rate at the initiation of dialysis. Propensity score matching (PSM) was used to compare the overall survival rate, cardiovascular events, Kidney Disease Quality of Life Short Form 36 (KDQOL-36) results, Karnofsky performance scale values, Beck's depression inventory values, and subjective global assessments. Results: The mean patient age was 72.0 years, and 61.7% of the patients were male. Overall, the cumulative survival rates were lower in the early initiation group, although the difference was not significant after PSM. Additionally, the survival rates of the 2 groups did not differ after adjusting for age, sex, Charlson comorbidity index and hemoglobin, serum albumin, serum calcium and phosphorus levels. Although the early initiation group showed a lower physical component summary score on the KDQOL-36 3 months after dialysis, the difference in scores was not significant 12 months after dialysis. Furthermore, the difference was not significant after PSM. The Karnofsky performance scale, Beck's depression inventory, and subjective global assessments were not significantly different 3 and 12 months after dialysis initiation. Conclusions: The timing of dialysis initiation is not associated with clinical outcomes in elderly patients with ESRD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEarly dialysis initiation does not improve clinical outcomes in elderly end-stage renal disease patients: A multicenter prospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJae Yoon Park-
dc.contributor.googleauthorKyung Don Yoo-
dc.contributor.googleauthorYong Chul Kim-
dc.contributor.googleauthorDong Ki Kim-
dc.contributor.googleauthorKwon Wook Joo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorChul Woo Yang-
dc.contributor.googleauthorNam-Ho Kim-
dc.contributor.googleauthorYong-Lim Kim-
dc.contributor.googleauthorChun-Soo Lim-
dc.contributor.googleauthorYon Su Kim-
dc.contributor.googleauthorJung Pyo Lee-
dc.identifier.doi10.1371/journal.pone.0175830-
dc.contributor.localIdA00053-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28414758-
dc.subject.keywordAged-
dc.subject.keywordCalcium / blood-
dc.subject.keywordFemale-
dc.subject.keywordGlomerular Filtration Rate / physiology-
dc.subject.keywordHemoglobins / metabolism-
dc.subject.keywordHumans-
dc.subject.keywordKarnofsky Performance Status-
dc.subject.keywordKidney Failure, Chronic / blood-
dc.subject.keywordKidney Failure, Chronic / metabolism-
dc.subject.keywordKidney Failure, Chronic / physiopathology*-
dc.subject.keywordKidney Failure, Chronic / therapy*-
dc.subject.keywordMale-
dc.subject.keywordPhosphorus / blood-
dc.subject.keywordPropensity Score-
dc.subject.keywordProspective Studies-
dc.subject.keywordQuality of Life-
dc.subject.keywordRenal Dialysis / methods-
dc.subject.keywordRenal Insufficiency, Chronic / blood-
dc.subject.keywordRenal Insufficiency, Chronic / metabolism-
dc.subject.keywordRenal Insufficiency, Chronic / pathology-
dc.subject.keywordRenal Insufficiency, Chronic / therapy-
dc.subject.keywordSerum Albumin / metabolism-
dc.subject.keywordSurvival Rate-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.citation.volume12-
dc.citation.number4-
dc.citation.startPagee0175830-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(4) : e0175830, 2017-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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