Prevalence of retinal nerve fiber layer defects: The Korea National Health and Nutrition Examination Survey 2008-2012
Authors
Kyeong Ik Na ; Jin Wook Jeoung ; Won June Lee ; Young Kook Kim ; Chan Yun Kim ; Ki Ho Park ; Epidemiologic Survey Committee of the Korean Ophthalmologic Society
Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers / pathology* ; Nutrition Surveys ; Prevalence ; Republic of Korea ; Retina* ; Young Adult
Abstract
Purpose: To investigate the prevalence and associated factors of retinal nerve fiber layer defects (RNFLDs) in a Korean population.
Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) is a population-based study using a complex, stratified, multistage, probability-cluster survey. We performed a review of 2008-2012 data from the KNHANES. Two masked ophthalmologists evaluated fundus photography to detect RNFLDs. All participants underwent ocular and systemic evaluations.
Results: A total of 28,637 subjects aged ≥ 19 years with at least one evaluable fundus photograph were enrolled. The estimated prevalence of RNFLDs in this Korean population was 4.8% (95% confidence interval, 4.4%-5.3%). The estimated percentages of glaucomatous RNFLD and non-glaucomatous RNFLD subjects were 34.4% and 65.6%, respectively. In a multivariate analysis, the prevalence of RNFLDs was significantly associated with older age (P < 0.001), male gender (P = 0.047), glycosylated hemoglobin (P = 0.048), disc hemorrhage (P = 0.016), ISNT rule (P < 0.001), and vertical cup to disc ratio (P < 0.001).
Conclusions: The prevalence of RNFLDs in a large Korean population-based sample with a minimum age of 19 years was 4.8%. RNFLD prevalence was associated with old age, male gender, glycosylated hemoglobin, disc hemorrhage, and glaucomatous optic disc.