Cited 19 times in
Chronic Kidney Disease-Mineral Bone Disorder in Korean Patients: a Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD)
DC Field | Value | Language |
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dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2023-08-09T02:43:45Z | - |
dc.date.available | 2023-08-09T02:43:45Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195783 | - |
dc.description.abstract | This study examined the characteristics of biochemical parameters, bone diseases, and vascular calcification in Korean patients with chronic kidney disease (CKD) not yet on dialysis. Serum levels of fibroblast growth factor 23 (FGF23), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D3 (25D), and 1,25-dihydroxyvitamin D3 (1,25D); lumbar spine, total hip, and femur neck bone mineral densities; and brachial-to-ankle pulse wave velocity (baPWV) representing vascular calcification were measured at baseline for 2,238 CKD patients in the KoreaN Cohort Study for Outcomes in Patients With CKD (KNOW-CKD). Increases in serum FGF23 and iPTH preceded changes in serum calcium and phosphate, similar to Western populations. However, the 25D and 1,25D levels decreased earlier than serum FGF23 or iPTH increased, with a decreased estimated glomerular filtration rate (eGFR) in Korean CKD patients. Vitamin D deficiency occurred in 76.7% of patients with CKD stage 1. Bone mineral densities were lowest in CKD stage 5 (lumbar spine, -0.64 ± 1.67; total hip, -0.49 ± 1.21; femur neck, -1.02 ± 1.25). Osteoporosis was more prevalent in patients with higher CKD stages. The mean baPWV, abdominal aortic calcification (AAC), and coronary calcium score also increased, with declined eGFR. In conclusion, a decline in serum vitamin D levels was observed in early CKD stages before significant increases of FGF23 and iPTH in the Korean CKD population compared with that in Western populations. Increased bone disease and vascular calcification occurred in early-stage CKD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian People | - |
dc.subject.MESH | Bone Density | - |
dc.subject.MESH | Bone Diseases / complications | - |
dc.subject.MESH | Bone Diseases / pathology* | - |
dc.subject.MESH | Calcitriol / blood | - |
dc.subject.MESH | Calcium / blood | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblast Growth Factor-23 | - |
dc.subject.MESH | Fibroblast Growth Factors / blood | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parathyroid Hormone / blood | - |
dc.subject.MESH | Phosphates / blood | - |
dc.subject.MESH | Pulse Wave Analysis | - |
dc.subject.MESH | Renal Insufficiency, Chronic / complications | - |
dc.subject.MESH | Renal Insufficiency, Chronic / pathology* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Vitamin D / analogs & derivatives | - |
dc.subject.MESH | Vitamin D / blood | - |
dc.subject.MESH | Vitamin D Deficiency / epidemiology | - |
dc.title | Chronic Kidney Disease-Mineral Bone Disorder in Korean Patients: a Report from the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chang Seong Kim | - |
dc.contributor.googleauthor | Eun Hui Bae | - |
dc.contributor.googleauthor | Seong Kwon Ma | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Kyu Beck Lee | - |
dc.contributor.googleauthor | Joongyub Lee | - |
dc.contributor.googleauthor | Kook Hwan Oh | - |
dc.contributor.googleauthor | Dong Wan Chae | - |
dc.contributor.googleauthor | Soo Wan Kim | - |
dc.contributor.googleauthor | KNOW-CKD Study Group | - |
dc.identifier.doi | 10.3346/jkms.2017.32.2.240 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 28049234 | - |
dc.subject.keyword | Bone Diseases | - |
dc.subject.keyword | Chronic Kidney Disease | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | Vascular Calcification | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 240 | - |
dc.citation.endPage | 248 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(2) : 240-248, 2017-02 | - |
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