Cited 5 times in
Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans
DC Field | Value | Language |
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dc.contributor.author | 이상학 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2023-08-09T02:42:41Z | - |
dc.date.available | 2023-08-09T02:42:41Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0022-1333 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195768 | - |
dc.description.abstract | Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability inMI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer India in co-pulbication with Indian Academy of Sciences | - |
dc.relation.isPartOf | JOURNAL OF GENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adaptor Proteins, Signal Transducing | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian People / genetics | - |
dc.subject.MESH | Carrier Proteins / genetics* | - |
dc.subject.MESH | Exome Sequencing | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glucosyltransferases / genetics* | - |
dc.subject.MESH | Glycoproteins / genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction / genetics* | - |
dc.subject.MESH | Myocardial Infarction / pathology | - |
dc.subject.MESH | Polymorphism, Single Nucleotide / genetics | - |
dc.subject.MESH | Ribonucleases / genetics* | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji-Young Lee | - |
dc.contributor.googleauthor | Sanghoon Moon | - |
dc.contributor.googleauthor | Yun Kyoung Kim | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Bok-Soo Lee | - |
dc.contributor.googleauthor | Min-Young Park | - |
dc.contributor.googleauthor | Jeong Euy Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Bok-Ghee Han | - |
dc.identifier.doi | 10.1007/s12041-017-0854-z | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J04472 | - |
dc.identifier.eissn | 0973-7731 | - |
dc.identifier.pmid | 29321365 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12041-017-0854-z | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 96 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1041 | - |
dc.citation.endPage | 1046 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GENETICS, Vol.96(6) : 1041-1046, 2017-12 | - |
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