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Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.contributor.author | 김원호 | - |
dc.date.accessioned | 2023-08-09T02:42:33Z | - |
dc.date.available | 2023-08-09T02:42:33Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195765 | - |
dc.description.abstract | Background and aim: The present study evaluated the clinical characteristics of Korean patients with Crohn's disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study. Methods: A total of 1224 patients diagnosed with CD between 1982 and 2008 in 32 hospitals were included, and age at diagnosis was categorized as ≤ 16 (G1), 17-40 (G2), 41-59 (G3) and ≥ 60 (G4) years old. The baseline characteristics, medication, and intestinal resection were compared according to the age at diagnosis. Results: The number of patients in each age group was 155 (G1; 12.7%), 919 (G2; 75.1%), 120 (G3; 9.8%), and 30 (G4; 2.5%). The frequencies of ileocolonic disease in the late adult onset and elderly onset groups were lower than those in the other groups (P < 0.001). The cumulative probabilities of thiopurine and anti-tumor necrosis factor use in late adult onset and elderly onset groups were significantly reduced compared with those of the other groups (P < 0.01). However, the risk of the first intestinal resection was not different among the age groups. The ileal location (hazard ratio [HR]: 1.59; 95% confidence interval [CI]: 1.11-2.27), complicated behavior (HR: 3.35; 95% CI: 2.63-4.27), and early thiopurine use (HR: 0.27; 95% CI: 0.17-0.43) were associated with the first intestinal resection, whereas the age at diagnosis was not a risk factor. Conclusions: Elderly onset CD may be related to favorable outcomes in Korea. Thus, the heterogeneity of this disease should be considered when developing a tailored strategy for the treatment of CD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adalimumab / therapeutic use | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age of Onset* | - |
dc.subject.MESH | Azathioprine / therapeutic use | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Crohn Disease / diagnosis* | - |
dc.subject.MESH | Crohn Disease / drug therapy | - |
dc.subject.MESH | Crohn Disease / epidemiology* | - |
dc.subject.MESH | Crohn Disease / surgery | - |
dc.subject.MESH | Digestive System Surgical Procedures | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infliximab / therapeutic use | - |
dc.subject.MESH | Intestines / surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mercaptopurine / therapeutic use | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multicenter Studies as Topic | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Wook Hwang | - |
dc.contributor.googleauthor | Jee Hyun Kim | - |
dc.contributor.googleauthor | Jong Pil Im | - |
dc.contributor.googleauthor | Byong Duk Ye | - |
dc.contributor.googleauthor | Hoon Sup Koo | - |
dc.contributor.googleauthor | Kyu Chan Huh | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | You Sun Kim | - |
dc.contributor.googleauthor | Young Ho Kim | - |
dc.contributor.googleauthor | Dong Soo Han | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Joo Sung Kim Crohn's disease clinical network and cohort (CONNECT) study | - |
dc.identifier.doi | 10.1111/jgh.13775 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 28251684 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/jgh.13775 | - |
dc.subject.keyword | Crohn's disease | - |
dc.subject.keyword | age at diagnosis | - |
dc.subject.keyword | intestinal resection | - |
dc.subject.keyword | medication | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1716 | - |
dc.citation.endPage | 1722 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.32(10) : 1716-1722, 2017-10 | - |
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