Cited 31 times in
Quality of Anticoagulation with Warfarin in Korean Patients with Atrial Fibrillation and Prior Stroke: A Multicenter Retrospective Observational Study
DC Field | Value | Language |
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dc.contributor.author | 남효석 | - |
dc.date.accessioned | 2023-08-09T02:41:20Z | - |
dc.date.available | 2023-08-09T02:41:20Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195751 | - |
dc.description.abstract | Background and purpose: The quality of anticoagulation is critical for ensuring the benefit of warfarin, but this has been less well studied in Korean ischemic stroke patients with atrial fibrillation (AF). Methods: This study retrospectively analyzed the data of patients who had an AF-related ischemic stroke and were treated with long-term warfarin therapy in 16 Korean centers. The quality of warfarin therapy was primarily assessed by the time in therapeutic range [TTR; international normalized ratio (INR), 2.0-3.0] and additionally by the proportion of INR values within the therapeutic range. Results: The long-term warfarin-treated cohort comprised 1,230 patients. They were aged 70.1±9.7 years (mean±SD), 42.5% were female, and their CHA₂DS₂-VASc score was 4.75±1.41. The TTR analysis included 33,941 INR measurements for 27,487 months: per patients, 27.6 (SD, 22.4) INR measurements for 22.4 (SD, 12.9) months. The mean TTR of individual patients was 49.1% (95% confidence interval, 47.9-50.3%), and the TTR quartiles were <34.5, 34.5-49.1, 49.1-64.5%, and >64.5%. None of the 16 centers achieved a mean TTR of >60%. Of all INR measurements, 44.6% were within the therapeutic range, 41.7% were <2.0, and 13.7% were >3.0. Conclusions: In Korean ischemic stroke patients who had AF, the quality of warfarin therapy was low and might be inadequate to effectively prevent recurrent stroke or systemic embolism. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Neurological Association | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Quality of Anticoagulation with Warfarin in Korean Patients with Atrial Fibrillation and Prior Stroke: A Multicenter Retrospective Observational Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Keun Sik Hong | - |
dc.contributor.googleauthor | Yang Ki Kim | - |
dc.contributor.googleauthor | Hee Joon Bae | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Sun U Kwon | - |
dc.contributor.googleauthor | Oh Young Bang | - |
dc.contributor.googleauthor | Jae Kwan Cha | - |
dc.contributor.googleauthor | Byung Woo Yoon | - |
dc.contributor.googleauthor | Joung Ho Rha | - |
dc.contributor.googleauthor | Byung Chul Lee | - |
dc.contributor.googleauthor | Jong Moo Park | - |
dc.contributor.googleauthor | Man Seok Park | - |
dc.contributor.googleauthor | Jun Lee | - |
dc.contributor.googleauthor | Jay Chol Choi | - |
dc.contributor.googleauthor | Dong Eog Kim | - |
dc.contributor.googleauthor | Kyung Bok Lee | - |
dc.contributor.googleauthor | Tai Hwan Park | - |
dc.contributor.googleauthor | Ji Sung Lee | - |
dc.contributor.googleauthor | Seong Eun Kim | - |
dc.contributor.googleauthor | Juneyoung Lee | - |
dc.identifier.doi | 10.3988/jcn.2017.13.3.273 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A01036 | - |
dc.relation.journalcode | J01327 | - |
dc.identifier.eissn | 2005-5013 | - |
dc.identifier.pmid | 28748679 | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | quality | - |
dc.subject.keyword | seconadry stroke prevention | - |
dc.subject.keyword | time in therapeutic range | - |
dc.subject.keyword | warfarin | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 273 | - |
dc.citation.endPage | 280 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, Vol.13(3) : 273-280, 2017-07 | - |
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