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The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015

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dc.contributor.author지선하-
dc.date.accessioned2023-08-09T02:40:22Z-
dc.date.available2023-08-09T02:40:22Z-
dc.date.issued2017-12-
dc.identifier.issn2374-2437-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195735-
dc.description.abstractImportance: Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use. Objective: To report results of the Global Burden of Disease (GBD) 2015 study on primary liver cancer incidence, mortality, and disability-adjusted life-years (DALYs) for 195 countries or territories from 1990 to 2015, and present global, regional, and national estimates on the burden of liver cancer attributable to HBV, HCV, alcohol, and an “other” group that encompasses residual causes. Design, Settings, and Participants: Mortality was estimated using vital registration and cancer registry data in an ensemble modeling approach. Single-cause mortality estimates were adjusted for all-cause mortality. Incidence was derived from mortality estimates and the mortality-to-incidence ratio. Through a systematic literature review, data on the proportions of liver cancer due to HBV, HCV, alcohol, and other causes were identified. Years of life lost were calculated by multiplying each death by a standard life expectancy. Prevalence was estimated using mortality-to-incidence ratio as surrogate for survival. Total prevalence was divided into 4 sequelae that were multiplied by disability weights to derive years lived with disability (YLDs). DALYs were the sum of years of life lost and YLDs. Main Outcomes and Measures: Liver cancer mortality, incidence, YLDs, years of life lost, DALYs by etiology, age, sex, country, and year. Results: There were 854 000 incident cases of liver cancer and 810 000 deaths globally in 2015, contributing to 20 578 000 DALYs. Cases of incident liver cancer increased by 75% between 1990 and 2015, of which 47% can be explained by changing population age structures, 35% by population growth, and −8% to changing age-specific incidence rates. The male-to-female ratio for age-standardized liver cancer mortality was 2.8. Globally, HBV accounted for 265 000 liver cancer deaths (33%), alcohol for 245 000 (30%), HCV for 167 000 (21%), and other causes for 133 000 (16%) deaths, with substantial variation between countries in the underlying etiologies. Conclusions and Relevance: Liver cancer is among the leading causes of cancer deaths in many countries. Causes of liver cancer differ widely among populations. Our results show that most cases of liver cancer can be prevented through vaccination, antiviral treatment, safe blood transfusion and injection practices, as well as interventions to reduce excessive alcohol use. In line with the Sustainable Development Goals, the identification and elimination of risk factors for liver cancer will be required to achieve a sustained reduction in liver cancer burden. The GBD study can be used to guide these prevention efforts.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Medical Association-
dc.relation.isPartOfJAMA ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlcohol Drinking / epidemiology*-
dc.subject.MESHFemale-
dc.subject.MESHGlobal Burden of Disease / statistics & numerical data*-
dc.subject.MESHGlobal Health-
dc.subject.MESHHepatitis B / complications-
dc.subject.MESHHepatitis B / epidemiology*-
dc.subject.MESHHepatitis C / complications-
dc.subject.MESHHepatitis C / epidemiology*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLiver Neoplasms / epidemiology*-
dc.subject.MESHLiver Neoplasms / etiology-
dc.subject.MESHMale-
dc.subject.MESHMortality-
dc.subject.MESHPrevalence-
dc.subject.MESHQuality-Adjusted Life Years-
dc.subject.MESHRegistries-
dc.titleThe Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorGlobal Burden of Disease Liver Cancer Collaboration-
dc.contributor.googleauthorTomi Akinyemiju-
dc.contributor.googleauthorSemaw Abera-
dc.contributor.googleauthorMuktar Ahmed-
dc.contributor.googleauthorNoore Alam-
dc.contributor.googleauthorMulubirhan Assefa Alemayohu-
dc.contributor.googleauthorChristine Allen-
dc.contributor.googleauthorRajaa Al-Raddadi-
dc.contributor.googleauthorNelson Alvis-Guzman-
dc.contributor.googleauthorYaw Amoako-
dc.contributor.googleauthorAl Artaman-
dc.contributor.googleauthorTadesse Awoke Ayele-
dc.contributor.googleauthorAleksandra Barac-
dc.contributor.googleauthorIsabela Bensenor-
dc.contributor.googleauthorAdugnaw Berhane-
dc.contributor.googleauthorZulfiqar Bhutta-
dc.contributor.googleauthorJacqueline Castillo-Rivas-
dc.contributor.googleauthorAbdulaal Chitheer-
dc.contributor.googleauthorJee-Young Choi-
dc.contributor.googleauthorBenjamin Cowie-
dc.contributor.googleauthorLalit Dandona-
dc.contributor.googleauthorRakhi Dandona-
dc.contributor.googleauthorSubhojit Dey-
dc.contributor.googleauthorDaniel Dicker-
dc.contributor.googleauthorHuyen Phuc-
dc.contributor.googleauthorDonatus U. Ekwueme-
dc.contributor.googleauthorMaysaa El Sayed Zaki-
dc.contributor.googleauthorFlorian Fischer-
dc.contributor.googleauthorThomas Fürst-
dc.contributor.googleauthorJamie Hancock-
dc.contributor.googleauthorSimon I. Hay-
dc.contributor.googleauthorPeter Hotez-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorAmir Kasaeian-
dc.contributor.googleauthorYousef Khader-
dc.contributor.googleauthorYoung-Ho Khang-
dc.contributor.googleauthorAnil Kumar-
dc.contributor.googleauthorMichael Kutz-
dc.contributor.googleauthorHeidi Larson-
dc.contributor.googleauthorAlan Lopez-
dc.contributor.googleauthorRaimundas Lunevicius-
dc.contributor.googleauthorReza Malekzadeh-
dc.contributor.googleauthorColm McAlinden-
dc.contributor.googleauthorToni Meier-
dc.contributor.googleauthorWalter Mendoza-
dc.contributor.googleauthorAli Mokdad-
dc.contributor.googleauthorMaziar Moradi-Lakeh-
dc.contributor.googleauthorGabriele Nagel-
dc.contributor.googleauthorQuyen Nguyen-
dc.contributor.googleauthorGrant Nguyen-
dc.contributor.googleauthorFelix Ogbo-
dc.contributor.googleauthorGeorge Patton-
dc.contributor.googleauthorDavid M. Pereira-
dc.contributor.googleauthorFarshad Pourmalek-
dc.contributor.googleauthorMostafa Qorbani-
dc.contributor.googleauthorAmir Radfar-
dc.contributor.googleauthorGholamreza Roshandel-
dc.contributor.googleauthorJoshua A Salomon-
dc.contributor.googleauthorJuan Sanabria-
dc.contributor.googleauthorBenn Sartorius-
dc.contributor.googleauthorMaheswar Satpathy-
dc.contributor.googleauthorMonika Sawhney-
dc.contributor.googleauthorSadaf Sepanlou-
dc.contributor.googleauthorKatya Shackelford-
dc.contributor.googleauthorHirbo Shore-
dc.contributor.googleauthorJiandong Sun-
dc.contributor.googleauthorDesalegn Tadese Mengistu-
dc.contributor.googleauthorRoman Topór-Mądry-
dc.contributor.googleauthorBach Tran-
dc.contributor.googleauthorKingsley Nnanna Ukwaja-
dc.contributor.googleauthorVasiliy Vlassov-
dc.contributor.googleauthorStein Emil Vollset-
dc.contributor.googleauthorTheo Vos-
dc.contributor.googleauthorTolassa Wakayo-
dc.contributor.googleauthorElisabete Weiderpass-
dc.contributor.googleauthorAndrea Werdecker-
dc.contributor.googleauthorNaohiro Yonemoto-
dc.contributor.googleauthorMustafa Younis-
dc.contributor.googleauthorChuanhua Yu-
dc.contributor.googleauthorZoubida Zaidi-
dc.contributor.googleauthorLiguo Zhu-
dc.contributor.googleauthorChristopher J. L. Murray-
dc.contributor.googleauthorMohsen Naghavi-
dc.contributor.googleauthorChristina Fitzmaurice-
dc.identifier.doi10.1001/jamaoncol.2017.3055-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ02919-
dc.identifier.eissn2374-2445-
dc.identifier.pmid28983565-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824275/?report=printable-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume3-
dc.citation.number12-
dc.citation.startPage1683-
dc.citation.endPage1691-
dc.identifier.bibliographicCitationJAMA ONCOLOGY, Vol.3(12) : 1683-1691, 2017-12-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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