Cited 3 times in
Reduction in microalbuminuria by calcium channel blockers in patients with type 2 diabetes mellitus and hypertension-A randomized, open-label, active-controlled, superiority, parallel-group clinical trial
DC Field | Value | Language |
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dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2023-08-09T02:39:27Z | - |
dc.date.available | 2023-08-09T02:39:27Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1368-5031 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195719 | - |
dc.description.abstract | Background: It has been suggested that renoprotection with calcium channel blockers (CCBs) may differ. This study aimed to compare the anti-proteinuric effect of different CCBs in patients with type 2 diabetes (T2D). Methods: A multicentre, randomized, open-label, active-controlled study was performed in seven centres in Korea. A total of 74 patients with T2D and microalbuminuria treated with renin-angiotensin system (RAS) blockers were randomized to a cilnidipine 10 mg treatment (n=38) or amlodipine 5 mg treatment (n=36). Results: Urine albumin to creatinine ratio (ACR) reduction was similar between the two groups at 12 weeks (-53.0±123.2 mg/g in cilnidipine group and -35.7±83.6 mg/g in amlodipine group, P=.29) or 24 weeks (-57.3±106.9 mg/g in cilnidipine group and -20.0±110.4 mg/g in amlodipine group, P=.24). In a subgroup analysis, cilnidipine treatment showed a larger ACR reduction than amlodipine treatment at 12 weeks (-84.7±106.8 mg/g in cilnidipine group and -9.5±79.2 mg/g in amlodipine group, P=.01) and 24 weeks (-84.0±111.7 mg/g in cilnidipine group and 14.6±119.4 mg/g in amlodipine group, P=.008), particularly in patients with a longer duration of diabetes more than 10 years. Conclusions: Cilnidipine did not show any additional anti-albuminuric effect compared with amlodipine in patients with T2D and microalbuminuria treated with an RAS blocker. However, the anti-albuminuric effect of cilnidipine might differ according to the duration of diabetes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Albuminuria / drug therapy* | - |
dc.subject.MESH | Albuminuria / etiology | - |
dc.subject.MESH | Amlodipine / therapeutic use* | - |
dc.subject.MESH | Calcium Channel Blockers / therapeutic use* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / complications* | - |
dc.subject.MESH | Dihydropyridines / therapeutic use* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension / complications* | - |
dc.subject.MESH | Hypertension / drug therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Reduction in microalbuminuria by calcium channel blockers in patients with type 2 diabetes mellitus and hypertension-A randomized, open-label, active-controlled, superiority, parallel-group clinical trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | You-Cheol Hwang | - |
dc.contributor.googleauthor | Kun-Ho Yoon | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.contributor.googleauthor | Kwan-Woo Lee | - |
dc.contributor.googleauthor | Hak Chul Jang | - |
dc.contributor.googleauthor | Kyung Wan Min | - |
dc.contributor.googleauthor | Choon Hee Chung | - |
dc.contributor.googleauthor | Moon-Kyu Lee | - |
dc.identifier.doi | 10.1111/ijcp.12987 | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J01099 | - |
dc.identifier.eissn | 1742-1241 | - |
dc.identifier.pmid | 28840637 | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | 차봉수 | - |
dc.citation.volume | 71 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e12987 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol.71(9) : e12987, 2017-09 | - |
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