Cited 92 times in
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.date.accessioned | 2023-08-09T02:37:10Z | - |
dc.date.available | 2023-08-09T02:37:10Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0959-8049 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195684 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The initiation of protein translation is an important rate-limiting step in eukaryotes and is crucial in many viral infections. Eukaryotic translation initiation factors (eIFs) are involved in the initiation step of protein translation and are linked to the phosphatidylinositol-3-kinases PI3K/AKT/mTOR pathway. Therefore we aimed to investigate a potential role of eIFs in HCC. We herein report on the immunohistochemical expression of the various eIF subunits in 235 cases of virus-related human HCC. Additionally, we used immunoblot analysis to investigate the expression of virus-related HCC and non-virus-related HCC in comparison to controls. Mammalian target of rapamycin (or mechanistic target of rapamycin as it is known now (mTOR) and activated mTOR were significantly increased in chronic hepatitis C (HCV)-associated HCC, in HCC without a viral background, in alcoholic liver disease and Wilson disease. pPTEN, phosphatase and tensin homologue (PTEN) and pAKT showed a significant increase in HBV- and HCV-associated HCC, chronic hepatitis B, HCC without a viral background, alcoholic steatohepatitis (ASH) and Wilson disease. Phosphorylated (p)-eIF2α, eIF2α, eiF3B, eIF3D, eIF3J, p-eIF4B, eIF4G and eIF6 were upregulated in HCV-associated HCC. eIF2α, p-eIF4B, eIF5 and various eIF3 subunits were significantly increased in chronic hepatitis B (HBV)-associated HCC. HCC without viral background displayed a significant increase for the eIF subunits p-2α, 3C, 3I, 4E and 4G. We noticed engraved differences in the expression pattern between chronic hepatitis B and C, HBV- and HCV-associated HCC and non-virus-related HCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Ltd | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor / metabolism* | - |
dc.subject.MESH | Carcinoma, Hepatocellular / complications | - |
dc.subject.MESH | Carcinoma, Hepatocellular / metabolism* | - |
dc.subject.MESH | Eukaryotic Initiation Factors / metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B, Chronic / complications | - |
dc.subject.MESH | Hepatitis B, Chronic / metabolism | - |
dc.subject.MESH | Hepatitis C, Chronic / complications | - |
dc.subject.MESH | Hepatitis C, Chronic / metabolism | - |
dc.subject.MESH | Hepatolenticular Degeneration / complications | - |
dc.subject.MESH | Hepatolenticular Degeneration / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Diseases, Alcoholic / complications | - |
dc.subject.MESH | Liver Diseases, Alcoholic / metabolism | - |
dc.subject.MESH | Liver Neoplasms / complications | - |
dc.subject.MESH | Liver Neoplasms / metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases / metabolism* | - |
dc.subject.MESH | Protein Subunits / metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt / metabolism* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | TOR Serine-Threonine Kinases / metabolism* | - |
dc.title | New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Nicole Golob-Schwarzl | - |
dc.contributor.googleauthor | Stefanie Krassnig | - |
dc.contributor.googleauthor | Anna M Toeglhofer | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Margit Gogg-Kamerer | - |
dc.contributor.googleauthor | Klemens Vierlinger | - |
dc.contributor.googleauthor | Fabian Schröder | - |
dc.contributor.googleauthor | Hyungjn Rhee | - |
dc.contributor.googleauthor | Rudolf Schicho | - |
dc.contributor.googleauthor | Peter Fickert | - |
dc.contributor.googleauthor | Johannes Haybaeck | - |
dc.identifier.doi | 10.1016/j.ejca.2017.06.003 | - |
dc.contributor.localId | A01563 | - |
dc.relation.journalcode | J00809 | - |
dc.identifier.eissn | 1879-0852 | - |
dc.identifier.pmid | 28715695 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0959804917310298 | - |
dc.subject.keyword | Chronic hepatitis B | - |
dc.subject.keyword | Chronic hepatitis C | - |
dc.subject.keyword | Non-virus-related hepatocellular carcinoma | - |
dc.subject.keyword | Translation initiation | - |
dc.subject.keyword | Virus-related hepatocellular carcinoma | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.citation.volume | 83 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CANCER, Vol.83 : 56-70, 2017-09 | - |
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