Cited 37 times in
Biodegradable vascular stents with high tensile and compressive strength: a novel strategy for applying monofilaments via solid-state drawing and shaped-annealing processes
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2023-08-09T02:34:20Z | - |
dc.date.available | 2023-08-09T02:34:20Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195632 | - |
dc.description.abstract | Monofilaments such as those consisting of polyamide (PA), polydioxanone (PDS), and poly(vinylidene fluoride) (PVDF), have been commonly used in various industries. However, most are non-biodegradable, which is unfavorable for many biomedical applications. Although biodegradable polymers offer significant benefits, they are still limited by their weak mechanical properties, which is an obstacle for use as a biomaterial that requires high strength. To overcome the current limitations of biodegradable monofilaments, a novel solid-state drawing (SSD) process was designed to significantly improve the mechanical properties of both PA and poly(l-lactic acid) (PLLA) monofilaments in this study. Both PA and PLLA monofilaments exhibited more than two-fold increased tensile strength and a highly reduced thickness using SSD. In X-ray diffraction and scanning electron microscopy analyses, it was determined that SSD could not only promote the α-crystal phase, but also smoothen the surface of PLLA monofilaments. To apply SSD-monofilaments with superior properties to cardiovascular stents, a shaped-annealing (SA) process was designed as the follow-up process after SSD. Using this process, three types of vascular stents could be fabricated, composed of SSD-monofilaments: double-helix, single-spring and double-spring shaped stents. The annealing temperature was optimized at 80 °C to minimize the loss of mechanical and physical properties of SSD-monofilaments for secondary processing. All three types of vascular stents were tested according to ISO 25539-2. Consequently, it was confirmed that spring-shaped stents had good recovery rate values and a high compressive modulus. In conclusion, this study showed significantly improved mechanical properties of both tensile and compressive strength simultaneously and extended the potential for biomedical applications of monofilaments. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isPartOf | BIOMATERIALS SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biocompatible Materials / adverse effects | - |
dc.subject.MESH | Biocompatible Materials / chemistry* | - |
dc.subject.MESH | Compressive Strength | - |
dc.subject.MESH | Hemolysis | - |
dc.subject.MESH | Human Umbilical Vein Endothelial Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Materials Testing | - |
dc.subject.MESH | Nylons / adverse effects | - |
dc.subject.MESH | Nylons / chemistry* | - |
dc.subject.MESH | Polyesters / adverse effects | - |
dc.subject.MESH | Polyesters / chemistry* | - |
dc.subject.MESH | Prosthesis Design | - |
dc.subject.MESH | Stents* / adverse effects | - |
dc.subject.MESH | Tensile Strength | - |
dc.title | Biodegradable vascular stents with high tensile and compressive strength: a novel strategy for applying monofilaments via solid-state drawing and shaped-annealing processes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seung Hyuk Im | - |
dc.contributor.googleauthor | Chang Yong Kim | - |
dc.contributor.googleauthor | Youngmee Jung | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.identifier.doi | 10.1039/c7bm00011a | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J03578 | - |
dc.identifier.eissn | 2047-4849 | - |
dc.identifier.pmid | 28184401 | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2017/BM/C7BM00011A | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | 장양수 | - |
dc.citation.volume | 5 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 422 | - |
dc.citation.endPage | 431 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS SCIENCE, Vol.5(3) : 422-431, 2017-03 | - |
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