Cited 8 times in
β-cell serotonin production is associated with female sex, old age, and diabetes-free condition
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.contributor.author | 박준성 | - |
dc.date.accessioned | 2023-08-09T02:34:20Z | - |
dc.date.available | 2023-08-09T02:34:20Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195630 | - |
dc.description.abstract | Serotonin is known to be present in pancreatic β-cells and to play several physiological roles, including insulin secretion, β-cell proliferation, and paracrine inhibition of α-cells. However, the serotonin production of different cell lines and islets has not been compared based on age, sex, and diabetes related conditions. Here, we directly compared the serotonin concentrations in βTC and MIN6 cell lines, as well as in islets from mice using ultra-performance liquid chromatography tandem mass spectrometry. The average serotonin concentration was 5-10 ng/mg protein in the islets of male and non-pregnant female mice. The serotonin level was higher in females than males at 8 weeks, although there was no difference at 1 year. Furthermore, we observed serotonin by immunofluorescence staining in the pancreatic tissues of mice and human. Serotonin was detected by immunofluorescence staining in a portion of β-cells from islets of old female mice, but not of male or young female mice. A similar pattern was observed in human pancreas as well. In humans, serotonin production in β-cells was associated with a diabetes-free condition. Thus, serotonin production in β-cells was associated with old age, female sex, and diabetes-free condition. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Chromatography, Liquid / methods | - |
dc.subject.MESH | Diabetes Mellitus / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorescent Antibody Technique / methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin-Secreting Cells / metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Ovariectomy | - |
dc.subject.MESH | Serotonin / analysis | - |
dc.subject.MESH | Serotonin / metabolism* | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Tandem Mass Spectrometry | - |
dc.title | β-cell serotonin production is associated with female sex, old age, and diabetes-free condition | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yeong Gi Kim | - |
dc.contributor.googleauthor | Joon Ho Moon | - |
dc.contributor.googleauthor | Kyuho Kim | - |
dc.contributor.googleauthor | Hyeongseok Kim | - |
dc.contributor.googleauthor | Juok Kim | - |
dc.contributor.googleauthor | Ji-Seon Jeong | - |
dc.contributor.googleauthor | Junguee Lee | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.contributor.googleauthor | Joon Seong Park | - |
dc.contributor.googleauthor | Hail Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.09.130 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 28958940 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0006291X17319113 | - |
dc.subject.keyword | Age | - |
dc.subject.keyword | Diabetes | - |
dc.subject.keyword | Islet | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Sex | - |
dc.subject.keyword | β-cell | - |
dc.citation.volume | 493 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1197 | - |
dc.citation.endPage | 1203 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.493(3) : 1197-1203, 2017-11 | - |
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