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Proposed Nomogram Predicting the Individual Risk of Malignancy in the Patients With Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas
DC Field | Value | Language |
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dc.contributor.author | 이우정 | - |
dc.contributor.author | 강창무 | - |
dc.date.accessioned | 2023-08-09T02:32:09Z | - |
dc.date.available | 2023-08-09T02:32:09Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195616 | - |
dc.description.abstract | Objectives: This study evaluated individual risks of malignancy and proposed a nomogram for predicting malignancy of branch duct type intraductal papillary mucinous neoplasms (BD-IPMNs) using the large database for IPMN. Background: Although consensus guidelines list several malignancy predicting factors in patients with BD-IPMN, those variables have different predictability and individual quantitative prediction of malignancy risk is limited. Methods: Clinicopathological factors predictive of malignancy were retrospectively analyzed in 2525 patients with biopsy proven BD-IPMN at 22 tertiary hospitals in Korea and Japan. The patients with main duct dilatation >10 mm and inaccurate information were excluded. Results: The study cohort consisted of 2258 patients. Malignant IPMNs were defined as those with high grade dysplasia and associated invasive carcinoma. Of 2258 patients, 986 (43.7%) had low, 443 (19.6%) had intermediate, 398 (17.6%) had high grade dysplasia, and 431 (19.1%) had invasive carcinoma. To construct and validate the nomogram, patients were randomly allocated into training and validation sets, with fixed ratios of benign and malignant lesions. Multiple logistic regression analysis resulted in five variables (cyst size, duct dilatation, mural nodule, serum CA19-9, and CEA) being selected to construct the nomogram. In the validation set, this nomogram showed excellent discrimination power through a 1000 times bootstrapped calibration test. Conclusion: A nomogram predicting malignancy in patients with BD-IPMN was constructed using a logistic regression model. This nomogram may be useful in identifying patients at risk of malignancy and for selecting optimal treatment methods. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma, Mucinous / pathology* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | CA-19-9 Antigen / blood | - |
dc.subject.MESH | Carcinoembryonic Antigen / blood | - |
dc.subject.MESH | Carcinoma, Pancreatic Ductal / pathology* | - |
dc.subject.MESH | Carcinoma, Papillary / pathology* | - |
dc.subject.MESH | Dilatation, Pathologic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Nomograms* | - |
dc.subject.MESH | Pancreatic Ducts / pathology | - |
dc.subject.MESH | Pancreatic Neoplasms / pathology* | - |
dc.subject.MESH | Precancerous Conditions / pathology* | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Proposed Nomogram Predicting the Individual Risk of Malignancy in the Patients With Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jin-Young Jang | - |
dc.contributor.googleauthor | Taesung Park | - |
dc.contributor.googleauthor | Selyeong Lee | - |
dc.contributor.googleauthor | Yongkang Kim | - |
dc.contributor.googleauthor | Seung Yeoun Lee | - |
dc.contributor.googleauthor | Sun-Whe Kim | - |
dc.contributor.googleauthor | Song-Cheol Kim | - |
dc.contributor.googleauthor | Ki-Byung Song | - |
dc.contributor.googleauthor | Masakazu Yamamoto | - |
dc.contributor.googleauthor | Takashi Hatori | - |
dc.contributor.googleauthor | Seiko Hirono | - |
dc.contributor.googleauthor | Sohei Satoi | - |
dc.contributor.googleauthor | Tsutomu Fujii | - |
dc.contributor.googleauthor | Satoshi Hirano | - |
dc.contributor.googleauthor | Yasushi Hashimoto | - |
dc.contributor.googleauthor | Yashuhiro Shimizu | - |
dc.contributor.googleauthor | Dong Wook Choi | - |
dc.contributor.googleauthor | Seong Ho Choi | - |
dc.contributor.googleauthor | Jin Seok Heo | - |
dc.contributor.googleauthor | Fuyuhiko Motoi | - |
dc.contributor.googleauthor | Ippei Matsumoto | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Chang Moo Kang | - |
dc.contributor.googleauthor | Ho-Seong Han | - |
dc.contributor.googleauthor | Yoo-Seok Yoon | - |
dc.contributor.googleauthor | Masayuki Sho | - |
dc.contributor.googleauthor | Hiroaki Nagano | - |
dc.contributor.googleauthor | Goro Honda | - |
dc.contributor.googleauthor | Sang Geol Kim | - |
dc.contributor.googleauthor | Hee Chul Yu | - |
dc.contributor.googleauthor | Jun Chul Chung | - |
dc.contributor.googleauthor | Yuichi Nagakawa | - |
dc.contributor.googleauthor | Hyung Il Seo | - |
dc.contributor.googleauthor | Hiroki Yamaue | - |
dc.identifier.doi | 10.1097/SLA.0000000000001985 | - |
dc.contributor.localId | A02993 | - |
dc.contributor.localId | A00088 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 27607098 | - |
dc.identifier.url | https://journals.lww.com/annalsofsurgery/Fulltext/2017/12000/Proposed_Nomogram_Predicting_the_Individual_Risk.26.aspx | - |
dc.contributor.alternativeName | Lee, Woo Jung | - |
dc.contributor.affiliatedAuthor | 이우정 | - |
dc.contributor.affiliatedAuthor | 강창무 | - |
dc.citation.volume | 266 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1062 | - |
dc.citation.endPage | 1068 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.266(6) : 1062-1068, 2017-12 | - |
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