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Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.date.accessioned | 2023-07-25T04:52:12Z | - |
dc.date.available | 2023-07-25T04:52:12Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195575 | - |
dc.description.abstract | We delved into the expression of amine oxidase family proteins and their potential significance in adrenal gland neoplasm. Tissue microarrays were prepared for 132 cases of adrenal cortical neoplasm (ACN) consisting of 115 cases of adrenal cortical adenoma (ACA), 17 cases of adrenal cortical carcinoma (ACC), and 163 cases of pheochromocytoma (PCC). Immunohistochemical stainings for MAOA, MAOB, LOX, and AOC3 were performed to evaluate the H-scores and compare them with clinicopathological parameters. The H-scores of MAOA (T; p = 0.005) and MAOB (T; p = 0.006) in tumor cells (T) were high in ACN, whereas LOX (T, S; p < 0.001) in tumor and stromal cells (S) and AOC3 (T; p < 0.001) were higher in PCC. In stromal cells, MAOA (S; p < 0.001) and AOC3 (S; p = 0.010) were more expressed in ACA than in ACC. MAOB (S) in PCC showed higher H-scores when the grading of adrenal pheochromocytoma and paraganglioma (GAPP) score was 3 or higher (p = 0.027). In the univariate analysis, low MAOA expression in stromal cells of ACN was associated with shorter overall survival (p = 0.008). In conclusion, monoamine oxidase proteins revealed differences in expression between ACN and PCC and also between benign and malignant cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | BIOMEDICINES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Eun Kyung Kim | - |
dc.contributor.googleauthor | Seung Koo | - |
dc.identifier.doi | 10.3390/biomedicines11071896 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J03914 | - |
dc.identifier.eissn | 2227-9059 | - |
dc.subject.keyword | adrenal gland tumor | - |
dc.subject.keyword | adrenal cortical tumor | - |
dc.subject.keyword | pheochromocytoma | - |
dc.subject.keyword | amine oxidase protein | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1896 | - |
dc.identifier.bibliographicCitation | BIOMEDICINES, Vol.11(7) : 1896, 2023-07 | - |
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