121 215

Cited 0 times in

Sirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model

DC Field Value Language
dc.contributor.author윤영남-
dc.contributor.author김정환-
dc.date.accessioned2023-07-12T03:18:05Z-
dc.date.available2023-07-12T03:18:05Z-
dc.date.issued2023-02-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195566-
dc.description.abstractWe investigated the role of a sirolimus-embedded silk microneedle (MN) wrap as an external vascular device for drug delivery efficacy, inhibition of neointimal hyperplasia, and vascular remodeling. Using dogs, a vein graft model was developed to interpose the carotid or femoral artery with the jugular or femoral vein. The control group contained four dogs with only interposed grafts; the intervention group contained four dogs with vein grafts in which sirolimus-embedded silk-MN wraps were applied. After 12-weeks post-implantation, 15 vein grafts in each group were explanted and analyzed. Vein grafts applied with the rhodamine B-embedded silk-MN wrap showed far higher fluorescent signals than those without the wrap. The diameter of vein grafts in the intervention group decreased or remained stable without dilatation; however, it increased in the control group. The intervention group had femoral vein grafts with a significantly lower mean neointima-to-media ratio, and had vein grafts with an intima layer showing a significantly lower collagen density ratio than the control group. In conclusion, sirolimus-embedded silk-MN wrap in a vein graft model successfully delivered the drug to the intimal layer of the vein grafts. It prevented vein graft dilatation, avoiding shear stress and decreasing wall tension, and it inhibited neointimal hyperplasia.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCarotid Arteries-
dc.subject.MESHDogs-
dc.subject.MESHDrug Delivery Systems-
dc.subject.MESHHyperplasia-
dc.subject.MESHNeointima* / prevention & control-
dc.subject.MESHSirolimus* / pharmacology-
dc.titleSirolimus-Embedded Silk Microneedle Wrap to Prevent Neointimal Hyperplasia in Vein Graft Model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorJung-Hwan Kim-
dc.contributor.googleauthorEui Hwa Jang-
dc.contributor.googleauthorJi-Yeon Ryu-
dc.contributor.googleauthorJiyong Lee-
dc.contributor.googleauthorJae Ho Kim-
dc.contributor.googleauthorWonhyoung Ryu-
dc.contributor.googleauthorYoung-Nam Youn-
dc.identifier.doi10.3390/ijms24043306-
dc.contributor.localIdA02576-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid36834717-
dc.subject.keywordmicroneedle-
dc.subject.keywordneointimal hyperplasia-
dc.subject.keywordperivascular drug delivery-
dc.subject.keywordsilk fibroin-
dc.subject.keywordvascular wraps-
dc.subject.keywordvein graft-
dc.contributor.alternativeNameYoun, Young Nam-
dc.contributor.affiliatedAuthor윤영남-
dc.citation.volume24-
dc.citation.number4-
dc.citation.startPage3306-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(4) : 3306, 2023-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.