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Phosphodiesterase-5 Inhibitor Use in Robot Assisted Radical Prostatectomy Patients Is Associated with Reduced Risk of Death: A Propensity Score Matched Analysis of 1,058 Patients
DC Field | Value | Language |
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dc.contributor.author | 이광석 | - |
dc.contributor.author | 이종수 | - |
dc.contributor.author | 장원식 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 한현호 | - |
dc.contributor.author | 허지은 | - |
dc.date.accessioned | 2023-07-12T03:02:25Z | - |
dc.date.available | 2023-07-12T03:02:25Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2287-4208 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195480 | - |
dc.description.abstract | Purpose: We investigated whether the use of a phosphodiesterase-5 inhibitor (PDE5i) after robot assited radical prostatectomy has a survival benefit over non-use patients because there are controversial results on the association between PDE5i use and survival outcomes for prostate cancer patients in literature. Materials and methods: We designed a retrospective, matched, large-sample cohort study of 5,545 patients who underwent robot assisted radical prostatectomy (RARP) during 2013-2021 in a single institute. The exclusion criteria was patients who were aged >70 years at surgery, American Society of Anesthesiologists (ASA) physical status classification grade 4 or 5, history of other malignancies, patients who started PDE5i 6 months after survery and patients with follow up period less than 24 months after surgery. Among the 1,843 included patients, 1,298 were PDE5i users, and 545 were PDE5i non-users. We performed propensity score matching (PSM) of PDE5i users (n=529) with non-users (n=529) by adjusting for the variables of age, Gleason grade group, pathological T stage, preoperative ASA physical status grade, and International Index of Erectile Function score. Results: There were no significant difference in patient characteristics according to PSM. Kaplan-Meier curve revealed the difference of overall survival for PDE5i users and non-users (clustered log-rank test p<0.05). In a stratified Cox regression analysis, PDE5i use after RARP was associated with improved overall survival and reduced risk of death (hazard ratio 0.43; confidence interval 0.24-0.79; p=0.007). The limitation of this study was that the indication for the prescription of PDE5i was not given. Conclusions: PDE5i administration after RARP were associated with overall survival of patients with prostate cancer. A further randomized control trial may reveal whether routine use of PDE5i after prostatectomy can improve survival of prostate cancer patient. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한남성과학회 | - |
dc.relation.isPartOf | WORLD JOURNAL OF MENS HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Phosphodiesterase-5 Inhibitor Use in Robot Assisted Radical Prostatectomy Patients Is Associated with Reduced Risk of Death: A Propensity Score Matched Analysis of 1,058 Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Jongsoo Lee | - |
dc.contributor.googleauthor | Hye Rim Kim | - |
dc.contributor.googleauthor | Ji Eun Heo | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.contributor.googleauthor | Sung Ku Kang | - |
dc.contributor.googleauthor | Hyunho Han | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.identifier.doi | 10.5534/wjmh.220063 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A05500 | - |
dc.contributor.localId | A05268 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04333 | - |
dc.contributor.localId | A05531 | - |
dc.relation.journalcode | J02798 | - |
dc.identifier.eissn | 2287-4690 | - |
dc.identifier.pmid | 36649919 | - |
dc.subject.keyword | Erectile dysfunction | - |
dc.subject.keyword | Phosphodiesterase 5 inhibitors | - |
dc.subject.keyword | Prostatectomy | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Lee, Kwang Suk | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 이종수 | - |
dc.contributor.affiliatedAuthor | 장원식 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 한현호 | - |
dc.contributor.affiliatedAuthor | 허지은 | - |
dc.citation.volume | 41 | - |
dc.citation.startPage | e14 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF MENS HEALTH, Vol.41 : e14, 2023-01 | - |
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