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Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정지예 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2023-07-12T02:59:33Z | - |
dc.date.available | 2023-07-12T02:59:33Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195462 | - |
dc.description.abstract | Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | COVID-19 Serotherapy | - |
dc.subject.MESH | COVID-19* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Rituximab / therapeutic use | - |
dc.subject.MESH | SARS-CoV-2* | - |
dc.subject.MESH | Steroids | - |
dc.title | Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yae Jee Baek | - |
dc.contributor.googleauthor | Gemma Park | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Bryan Inho Kim | - |
dc.contributor.googleauthor | Jin Gwack | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.identifier.doi | 10.3346/jkms.2023.38.e175 | - |
dc.contributor.localId | A03735 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 37272563 | - |
dc.subject.keyword | Coronavirus Disease 2019 | - |
dc.subject.keyword | Immunodeficiency | - |
dc.subject.keyword | SARS-CoV-2 | - |
dc.subject.keyword | Within-Host Evolution | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 22 | - |
dc.citation.startPage | e175 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.38(22) : e175, 2023-06 | - |
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