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Epidemiology of PAH in Korea: An Analysis of the National Health Insurance Data, 2002-2018
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 이호규 | - |
dc.contributor.author | 이혁희 | - |
dc.date.accessioned | 2023-07-12T02:50:56Z | - |
dc.date.available | 2023-07-12T02:50:56Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195417 | - |
dc.description.abstract | Background and Objectives: Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Recent advances in PAH-specific drugs have improved its outcomes, although the healthcare burden of novel therapeutics may lead to a discrepancy in outcomes between developing and developed countries. We analyzed how the epidemiology and clinical features of PAH has changed through the rapidly advancing healthcare infrastructure in South Korea. Methods: PAH was defined according to a newly devised 3-component algorithm. Using a nationwide health insurance claims database, we delineated annual trends in the prevalence, incidence, medication prescription pattern, and 5-year survival of PAH in Korea. Cumulative survival and potential predictors of mortality were also assessed among 2,151 incident PAH cases. Results: Between 2002 or 2004 and 2018, the prevalence and incidence of PAH increased 75-fold (0.4 to 29.9 per million people) and 12-fold (0.5 to 6.3 per million person-years), respectively. The proportion of patients on combination PAH-specific drug therapy has also steadily increased up to 29.0% in 2018. Among 2,151 incident PAH cases (median [interquartile range] age, 50 [37–62] years; 67.2% female), the 5-year survival rate and median survival duration were 71.8% and 13.1 years, respectively. Independent predictors of mortality were age, sex, etiology of PAH, diabetes, dyslipidemia, and chronic kidney disease. Conclusions: This nationwide study delineated that the prevalence and incidence of PAH have grown rapidly in Korea since the early 2000s. The use of combination therapy has also increased, and the 5-year survival rate of PAH in Korea was similar to those in western countries. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Epidemiology of PAH in Korea: An Analysis of the National Health Insurance Data, 2002-2018 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Albert Youngwoo Jang | - |
dc.contributor.googleauthor | Hyeok-Hee Lee | - |
dc.contributor.googleauthor | Hokyou Lee | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.contributor.googleauthor | Wook-Jin Chung | - |
dc.identifier.doi | 10.4070/kcj.2022.0231 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A05838 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 37161745 | - |
dc.subject.keyword | Asia | - |
dc.subject.keyword | Big data | - |
dc.subject.keyword | Drug combination | - |
dc.subject.keyword | Pulmonary arterial hypertension | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 이호규 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 313 | - |
dc.citation.endPage | 327 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.53(5) : 313-327, 2023-05 | - |
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