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Soluble receptors for advanced glycation end-products prevent unilateral ureteral obstruction-induced renal fibrosis
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2023-07-12T02:46:28Z | - |
dc.date.available | 2023-07-12T02:46:28Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195394 | - |
dc.description.abstract | Introduction: The receptor for advanced glycation end products (RAGE) and its ligands, such as high-mobility group protein box 1 (HMGB1), play an important role in the accumulation of extracellular matrix in chronic kidney diseases with tubulointerstitial fibrosis. Blocking RAGE signaling with soluble RAGE (sRAGE) is a therapeutic candidate for renal fibrosis. Methods: NRK-52E cells were stimulated with or without HMGB1 and incubated with sRAGE in vitro. Sprague-Dawley rats were intraperitoneally treated with sRAGE after unilateral ureteral obstruction (UUO) operation in vivo. Results: HMBG1-stimulated NRK-52E cells showed increased fibronectin expression, type I collagen, α-smooth muscle actin, and connective tissue growth factor, which were attenuated by sRAGE. The mitogen-activated protein kinase (MAPK) pathway and nuclear translocation of nuclear factor kappa B (NF-κB) were enhanced in NRK-52E cells exposed to HMBG1, and sRAGE treatment alleviated the activation of the MAPK and NF-κB pathways. In the UUO rat models, sRAGE significantly ameliorated the increased renal fibronectin, type I collagen, and α-smooth muscle actin expressions. Masson's trichrome staining confirmed the anti-fibrotic effect of sRAGE in the UUO rat model. RAGE also significantly attenuated the activation of the MAPK pathway and NF-κB, as well as the increased number of infiltrated macrophages within the tubulointerstitium in the kidney of the UUO rat models. Conclusion: These findings suggest that RAGE plays a pivotal role in the pathogenesis of renal fibrosis and that its inhibition by sRAGE may be a potential therapeutic approach for renal fibrosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Media | - |
dc.relation.isPartOf | FRONTIERS IN PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Soluble receptors for advanced glycation end-products prevent unilateral ureteral obstruction-induced renal fibrosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Hye-Young Kang | - |
dc.contributor.googleauthor | Gyuri Kim | - |
dc.contributor.googleauthor | Jimin Park | - |
dc.contributor.googleauthor | Bo Young Nam | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.identifier.doi | 10.3389/fphar.2023.1172269 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J03340 | - |
dc.identifier.eissn | 1663-9812 | - |
dc.identifier.pmid | 37261287 | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | receptor for advanced glycation end-products (RAGE) | - |
dc.subject.keyword | renal fibrosis | - |
dc.subject.keyword | soluble RAGE | - |
dc.subject.keyword | unilateral ureteral obstruction | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1172269 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHARMACOLOGY, Vol.14 : 1172269, 2023-05 | - |
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