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Laser-Responsive Shape Memory Device to Program the Stepwise Control of Intraocular Pressure in Glaucoma

Authors
 Kyubae Lee  ;  Wungrak Choi  ;  Si Yeong Kim  ;  Eon-Bee Lee  ;  Won Take Oh  ;  Jeongeun Park  ;  Chan Hee Lee  ;  Jihei Sara Lee  ;  Hyoung Won Bae  ;  Dong-Su Jang  ;  Kang Suk Lee  ;  Se Won Yi  ;  Mi-Lan Kang  ;  Chan Yun Kim  ;  Hak-Joon Sun 
Citation
 ADVANCED FUNCTIONAL MATERIALS, Vol.2300264 : 1-17, 2023-05 
Journal Title
ADVANCED FUNCTIONAL MATERIALS
ISSN
 1616-301X 
Issue Date
2023-05
Keywords
anti-fibrotic drug release ; clinician-specified control of intraocular pressure ; computational fluid dynamics modeling ; glaucoma ; laser-responsive shape memory polymers
Abstract
There is an unmet need in the glaucoma clinic to control changes in the intraocular pressure (IOP), i.e., patient-specific hypotony and tissue fibrosis-mediated ocular hypertension, owing to the fixed tube diameter of the glaucoma drainage device. As a potential solution, the tube diameter can be adjusted, depending on the IOP, by shape memory polymer (SMP) and clinical laser systems, which can control the energy level, focus, and frequency by minimizing untargeted influences. To develop a translatable device, a laser-responsive SMP with two additional elements: i) a tube with an intimal gel coating to release 5-fluorouracil as an anti-fibrotic drug and ii) a safety lock ring to block late hypotony in special cases is employed. When the SMP tube is inserted into a silicone tube and wrapped externally by the ring, intimal gel degradation and argon laser-triggered diameter increase enable a three-step IOP control. Sustained drug release of the intimal gel suppresses tissue fibrosis, and the ring prevents late hypotony by externally squeezing the silicone tube. The advanced design and functions are validated using computational in vitro and rabbit glaucoma models by determining clinic-friendly argon laser parameters.
Files in This Item:
T202302975.pdf Download
DOI
10.1002/adfm.202300264
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Mi-Lan(강미란)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Lee, Kyubae(이규배) ORCID logo https://orcid.org/0000-0002-1270-8554
Lee, Jihei Sara(이지혜)
Choi, Wungrak(최웅락) ORCID logo https://orcid.org/0000-0002-3015-2502
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195344
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