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Time-Varying Risk Factors for Incident Fractures in Kidney Transplant Recipients: A Nationwide Cohort Study in South Korea
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2023-07-12T02:33:28Z | - |
dc.date.available | 2023-07-12T02:33:28Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195340 | - |
dc.description.abstract | Little is known about the time-varying risk factors for fractures in kidney transplant recipients (KTRs). Using the Korea Organ Transplantation Registry, a nationwide cohort study of KTRs, the incidence, locations, and time-varying predictors of fractures were analyzed, including at baseline and post-transplant 6-month variables in KTRs who underwent KT between January 2014 and June 2019. Among 4134 KTRs, with a median follow-up of 2.94 years (12,441.04 person-years), 63 patients developed fractures. The cumulative 5-year incidence was 2.10%. The most frequent locations were leg (25.40%) and foot/ankle (22.22%). In multivariable analysis, older recipient age at baseline (hazard ratio [HR], 1.035; 95% confidence interval [CI], 1.007–1.064; p = 0.013) and higher tacrolimus trough level (HR, 1.112; 95% CI, 1.029–1.202; p = 0.029) were associated with higher risks for fractures. Pretransplant diabetes mellitus had a time-dependent impact on fractures, with increasing risk as time elapses (HR for diabetes mellitus 1.115; 95% CI, 0.439–2.832; HR for diabetes mellitus × time, 1.049; 95% CI, 1.007–1.094; p = 0.022). In conclusion, KTRs had a high risk of peripheral skeletal fractures in the first 5 years. At baseline recipient age, pretransplant diabetes mellitus and tacrolimus trough level after KT were responsible for the fractures in KTRs. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Time-Varying Risk Factors for Incident Fractures in Kidney Transplant Recipients: A Nationwide Cohort Study in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sang Hun Eum | - |
dc.contributor.googleauthor | Da Won Kim | - |
dc.contributor.googleauthor | Jeong-Hoon Lee | - |
dc.contributor.googleauthor | Jin Seok Jeon | - |
dc.contributor.googleauthor | Heungman Jun | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Hye Eun Yoon | - |
dc.contributor.googleauthor | On Behalf Of The Korean Organ Transplantation Registry Study Group | - |
dc.identifier.doi | 10.3390/jcm12062337 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 36983337 | - |
dc.subject.keyword | CKD-MBD | - |
dc.subject.keyword | bone disease | - |
dc.subject.keyword | fracture | - |
dc.subject.keyword | immunosuppression | - |
dc.subject.keyword | kidney transplantation | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2337 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.12(6) : 2337, 2023-03 | - |
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