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Increased Risks of Open-Angle Glaucoma in Untreated Hypertension

Authors
 Jihei Sara Lee  ;  Yong Joon Kim  ;  Sunyeup Kim  ;  Hyoung Won Bae  ;  Sung Soo Kim  ;  Seung Won Lee  ;  Chan Yun Kim 
Citation
 AMERICAN JOURNAL OF OPHTHALMOLOGY, Vol.252 : 111-120, 2023-04 
Journal Title
AMERICAN JOURNAL OF OPHTHALMOLOGY
ISSN
 0002-9394 
Issue Date
2023-04
Abstract
PURPOSE: Hypertension (HTN) has been associated with open-angle glaucoma (OAG), but whether elevated blood pressure (BP) alone is associated with OAG is unknown. Whether stage 1 hypertension, as per the 2017 American College of Cardiology/American Heart Association (ACC/AHA) BP guidelines, increases the risk of the disease is uncertain.

DESIGN: Retrospective, observational, cohort study.

METHODS: A total of 360,330 subjects who were ≥40 years of age and not taking antihypertensive or antiglaucoma drugs at the time of health examinations between January 1, 2002, and December 31, 2003, were included. Subjects were categorized based on their untreated BP, into normal BP (systolic BP [SBP] <120 and diastolic BP [DBP] <80 mm Hg; n = 104,304), elevated BP (SBP 120-129 and DBP <80 mm Hg; n = 33,139), stage 1 HTN (SBP 130-139 or DBP 80-89 mm Hg; n = 122,534), or stage 2 HTN (SBP ≥140 or DBP ≥90mm Hg; n = 100,353). Cox regression analysis was performed to calculate hazard ratios (HR) of OAG risk.

RESULTS: The mean age of the subjects was 51.17 ± 8.97 years, and 56.2% were male. During a mean follow-up period of 11.76 ± 1.37 years, 12,841 subjects (3.56%) were diagnosed with OAG. Multivariable-adjusted HRs (95% CIs) were 1.056 (0.985-1.132) for elevated BP, 1.101(1.050-1.155) for stage 1 HTN, and 1.114(1.060-1.170) for stage 2 HTN with normal BP as the reference.

CONCLUSIONS: The risk for OAG becomes greater with increases in untreated BP. Stage 1 HTN per the 2017 ACC/AHA BP guidelines is a significant risk factor for OAG. © 2023 Elsevier Inc.
Full Text
https://www.sciencedirect.com/science/article/pii/S0002939423001459
DOI
10.1016/j.ajo.2023.03.032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Yong Joon(김용준)
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Lee, Jihei Sara(이지혜)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195336
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