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Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 이주한 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 민은기 | - |
dc.contributor.author | 김덕기 | - |
dc.contributor.author | 임승혁 | - |
dc.contributor.author | 최문채 | - |
dc.date.accessioned | 2023-07-12T02:32:12Z | - |
dc.date.available | 2023-07-12T02:32:12Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195335 | - |
dc.description.abstract | Objectives: The risk factors for late-onset Pneumocystis jirovecii pneumonia (PCP) after liver transplantation (LT) have not been well studied. We aimed to analyze the clinical features preceding PCP in LT recipients that would guide individualized prophylaxis. Methods: Among 742 patients who underwent LT and routine PCP prophylaxis from January 2009 through December 2019 at Severance Hospital, 27 patients developed PCP. We conducted a retrospective case-control study matching each patient with four controls and analyzed the risk factors for late-onset PCP. Results: After 6 months, post-transplant PCP cases increased steadily with an overall incidence of 6.36 cases per 1000 patient-year. The PCP-related mortality was 37.0%. In the multivariate analyses, age at LT ≥65 years (odds ratio [OR], 13.305; 95% confidence interval [CI], 2.507-70.618; P = 0.002), cytomegalovirus infection (OR, 5.390; 95% CI, 1.602-18.132; P = 0.006), steroid pulse therapy (OR, 6.564; 95% CI, 1.984-21.719; P = 0.002), hepatocellular carcinoma recurrence (OR, 18.180; 95% CI, 3.420-96.636; P = 0.001), and lymphocytopenia (OR, 3.758; 95% CI, 1.176-12.013; P = 0.026) were independently associated with PCP. Conclusion: Late-onset PCP after routine prophylaxis after LT remains a lethal infection and is associated with age ≥65 years at LT, cytomegalovirus infection, steroid pulse therapy, hepatocellular carcinoma recurrence, and lymphocytopenia. Targeted prophylaxis considering these risk factors could improve the prevention of this potentially lethal complication. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cytomegalovirus Infections* / complications | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* | - |
dc.subject.MESH | Liver Transplantation* / adverse effects | - |
dc.subject.MESH | Lymphopenia* | - |
dc.subject.MESH | Pneumocystis carinii* | - |
dc.subject.MESH | Pneumonia, Pneumocystis* / drug therapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Steroids / therapeutic use | - |
dc.subject.MESH | Transplant Recipients | - |
dc.title | Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Eun-Ki Min | - |
dc.contributor.googleauthor | Juhan Lee | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Deok-Gie Kim | - |
dc.contributor.googleauthor | Seung Hyuk Yim | - |
dc.contributor.googleauthor | Mun Chae Choi | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.identifier.doi | 10.1016/j.ijid.2023.04.387 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03163 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J01125 | - |
dc.identifier.eissn | 1878-3511 | - |
dc.identifier.pmid | 37044172 | - |
dc.subject.keyword | Liver transplantation | - |
dc.subject.keyword | Pneumocystis jirovecii pneumonia | - |
dc.subject.keyword | Risk factor | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 이주한 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 131 | - |
dc.citation.startPage | 166 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.131 : 166-172, 2023-06 | - |
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