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Outcome of untreated low-level viremia versus antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis
DC Field | Value | Language |
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dc.contributor.author | 김범경 | - |
dc.contributor.author | 이혜원 | - |
dc.contributor.author | 임태섭 | - |
dc.date.accessioned | 2023-07-12T02:21:41Z | - |
dc.date.available | 2023-07-12T02:21:41Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195281 | - |
dc.description.abstract | BACKGROUND: Comparative outcomes of HBV-infected compensated cirrhosis with low-level viremia (LLV) versus maintained virological response (MVR) are unclear. We conducted a large, multiethnic, multicenter study to examine the natural history of LLV versus MVR in compensated cirrhosis. PATIENTS AND METHODS: We enrolled patients with HBV-infected compensated cirrhosis (n=2316) from 19 hospitals in South Korea, Singapore, and Japan. We defined the LLV group as untreated patients with ≥1 detectable serum HBV-DNA (20-2000 IU/mL), Spontaneous-MVR group as untreated patients with spontaneously achieved MVR, and antiviral therapy (AVT)-MVR group as patients achieving AVT-induced MVR. Study end points were HCC or hepatic decompensation. RESULTS: The annual HCC incidence was 2.7/100 person-years (PYs), 2.6/100 PYs, and 3.3/100 PYs for LLV (n=742), Spontaneous-MVR (n=333), and AVT-MVR (n=1241) groups, respectively ( p = 0.81 between LLV vs. Spontaneous-MVR groups and p = 0.37 between LLV vs. AVT-MVR groups). Similarly, the annual decompensation incidence was 1.6/100 PYs, 1.9/100 PYs, and 1.6/100 PYs for LLV, Spontaneous-MVR, and AVT-MVR groups, respectively ( p = 0.40 between LLV vs. Spontaneous-MVR groups and p = 0.83 between LLV vs. AVT-MVR groups). Multivariable analyses determined that HCC and decompensation risks in the LLV group were comparable to those with Spontaneous-MVR and AVT-MVR groups (all p >0.05). Propensity score matching also reproduced similar results for HCC and decompensation risks (all p >0.05 between LLV vs. Spontaneous-MVR groups and between LLV vs. AVT-MVR groups). CONCLUSIONS: Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared with Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research. Copyright © 2023 American Association for the Study of Liver Diseases. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antiviral Agents / therapeutic use | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / drug therapy | - |
dc.subject.MESH | DNA, Viral | - |
dc.subject.MESH | Hepatitis B virus / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis / epidemiology | - |
dc.subject.MESH | Liver Neoplasms* / drug therapy | - |
dc.subject.MESH | Viremia / drug therapy | - |
dc.title | Outcome of untreated low-level viremia versus antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Daniel Q Huang | - |
dc.contributor.googleauthor | Nobuharu Tamaki | - |
dc.contributor.googleauthor | Hyung Woong Lee | - |
dc.contributor.googleauthor | Soo Young Park | - |
dc.contributor.googleauthor | Yu Rim Lee | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.contributor.googleauthor | Seng Gee Lim | - |
dc.contributor.googleauthor | Tae Seop Lim | - |
dc.contributor.googleauthor | Masayuki Kurosaki | - |
dc.contributor.googleauthor | Hiroyuki Marusawa | - |
dc.contributor.googleauthor | Toshie Mashiba | - |
dc.contributor.googleauthor | Masahiko Kondo | - |
dc.contributor.googleauthor | Yasushi Uchida | - |
dc.contributor.googleauthor | Haruhiko Kobashi | - |
dc.contributor.googleauthor | Koichiro Furuta | - |
dc.contributor.googleauthor | Namiki Izumi | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Dong Hyun Sinn | - |
dc.identifier.doi | 10.1097/HEP.0000000000000037 | - |
dc.contributor.localId | A00487 | - |
dc.relation.journalcode | J00985 | - |
dc.identifier.eissn | 1527-3350 | - |
dc.identifier.pmid | 36633913 | - |
dc.identifier.url | https://journals.lww.com/hep/Fulltext/2023/05000/Outcome_of_untreated_low_level_viremia_versus.28.aspx | - |
dc.contributor.alternativeName | Kim, Beom Kyung | - |
dc.contributor.affiliatedAuthor | 김범경 | - |
dc.citation.volume | 77 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1746 | - |
dc.citation.endPage | 1756 | - |
dc.identifier.bibliographicCitation | HEPATOLOGY, Vol.77(5) : 1746-1756, 2023-05 | - |
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