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Outcome of untreated low-level viremia versus antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis

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dc.contributor.author김범경-
dc.contributor.author이혜원-
dc.contributor.author임태섭-
dc.date.accessioned2023-07-12T02:21:41Z-
dc.date.available2023-07-12T02:21:41Z-
dc.date.issued2023-05-
dc.identifier.issn0270-9139-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/195281-
dc.description.abstractBACKGROUND: Comparative outcomes of HBV-infected compensated cirrhosis with low-level viremia (LLV) versus maintained virological response (MVR) are unclear. We conducted a large, multiethnic, multicenter study to examine the natural history of LLV versus MVR in compensated cirrhosis. PATIENTS AND METHODS: We enrolled patients with HBV-infected compensated cirrhosis (n=2316) from 19 hospitals in South Korea, Singapore, and Japan. We defined the LLV group as untreated patients with ≥1 detectable serum HBV-DNA (20-2000 IU/mL), Spontaneous-MVR group as untreated patients with spontaneously achieved MVR, and antiviral therapy (AVT)-MVR group as patients achieving AVT-induced MVR. Study end points were HCC or hepatic decompensation. RESULTS: The annual HCC incidence was 2.7/100 person-years (PYs), 2.6/100 PYs, and 3.3/100 PYs for LLV (n=742), Spontaneous-MVR (n=333), and AVT-MVR (n=1241) groups, respectively ( p = 0.81 between LLV vs. Spontaneous-MVR groups and p = 0.37 between LLV vs. AVT-MVR groups). Similarly, the annual decompensation incidence was 1.6/100 PYs, 1.9/100 PYs, and 1.6/100 PYs for LLV, Spontaneous-MVR, and AVT-MVR groups, respectively ( p = 0.40 between LLV vs. Spontaneous-MVR groups and p = 0.83 between LLV vs. AVT-MVR groups). Multivariable analyses determined that HCC and decompensation risks in the LLV group were comparable to those with Spontaneous-MVR and AVT-MVR groups (all p >0.05). Propensity score matching also reproduced similar results for HCC and decompensation risks (all p >0.05 between LLV vs. Spontaneous-MVR groups and between LLV vs. AVT-MVR groups). CONCLUSIONS: Untreated LLV in HBV-infected compensated cirrhosis is not associated with increased risk of disease progression compared with Spontaneous-MVR and AVT-MVR. These data have important implications for practice and further research. Copyright © 2023 American Association for the Study of Liver Diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfHEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntiviral Agents / therapeutic use-
dc.subject.MESHCarcinoma, Hepatocellular* / drug therapy-
dc.subject.MESHDNA, Viral-
dc.subject.MESHHepatitis B virus / genetics-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis / epidemiology-
dc.subject.MESHLiver Neoplasms* / drug therapy-
dc.subject.MESHViremia / drug therapy-
dc.titleOutcome of untreated low-level viremia versus antiviral therapy-induced or spontaneous undetectable HBV-DNA in compensated cirrhosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDaniel Q Huang-
dc.contributor.googleauthorNobuharu Tamaki-
dc.contributor.googleauthorHyung Woong Lee-
dc.contributor.googleauthorSoo Young Park-
dc.contributor.googleauthorYu Rim Lee-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorSeng Gee Lim-
dc.contributor.googleauthorTae Seop Lim-
dc.contributor.googleauthorMasayuki Kurosaki-
dc.contributor.googleauthorHiroyuki Marusawa-
dc.contributor.googleauthorToshie Mashiba-
dc.contributor.googleauthorMasahiko Kondo-
dc.contributor.googleauthorYasushi Uchida-
dc.contributor.googleauthorHaruhiko Kobashi-
dc.contributor.googleauthorKoichiro Furuta-
dc.contributor.googleauthorNamiki Izumi-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorDong Hyun Sinn-
dc.identifier.doi10.1097/HEP.0000000000000037-
dc.contributor.localIdA00487-
dc.relation.journalcodeJ00985-
dc.identifier.eissn1527-3350-
dc.identifier.pmid36633913-
dc.identifier.urlhttps://journals.lww.com/hep/Fulltext/2023/05000/Outcome_of_untreated_low_level_viremia_versus.28.aspx-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.affiliatedAuthor김범경-
dc.citation.volume77-
dc.citation.number5-
dc.citation.startPage1746-
dc.citation.endPage1756-
dc.identifier.bibliographicCitationHEPATOLOGY, Vol.77(5) : 1746-1756, 2023-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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