Q Fever is caused by Coxiella burnetii an boligate intracellular parasite that lives within the phagolysosome of infected cells. The infection can be asymptomatic, acute or chronic. Latently infected hosts with an immunocompromised condition may reactivate and experience Q Fever . Several cases of Q fever were reported as a complication fo malignancy. Recently Coxiella burnetii infected human peripheral blood lymphocyte (PBL) has been reported to undergo hairy cell transformation and therefore we can suggest the relationship between Coxiella burnetii infection and hairy cell leukemia. We report here a case of Q fever in 47-year-old patient with invasive cervical carcinoma and review the literature related to this disease.