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Effects of dimethyl methylphosphonate (DMMP) and trimethylphosphate (TMP) on spermatogenesis of rat testis
DC Field | Value | Language |
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dc.contributor.author | 박찬일 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2023-07-12T00:31:50Z | - |
dc.date.available | 2023-07-12T00:31:50Z | - |
dc.date.issued | 1994-06 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195161 | - |
dc.description.abstract | Both dimethyl methylphosphonate (DMMP) and trimethylphosphate (TMP) are organophosphorous compounds that can evoke sterility in male rodents. The following studies examined the pathology of reproductive organ, especially on the testis, by light microscopy after treatment with both agents. Adult male rats were treated per oral with DMMP, 1,750 mg/Kg, for up to 12 weeks and per oral with TMP, 400 mg/Kg for up to 5 weeks. After 5 weeks of treatment with DMMP there were occasional multinucleated giant cells composed of late spermatids in stages X, XI, XII as well as cytoplasmic vacuolation of Sertoli cell. Anachronistic spermiations were seldom, if ever, seen throughout the experiment. After 7 weeks of DMMP those were markedly diminished. The overall changes after treatment with TMP are somewhat similar to those treated with DMMP. The major changes were composed of aggregate of multinucleated giant cells and maturation arrest at spermatid level, which appear immediately after administration of TMP. The peak frequency in the emergence of multinucleated giant cells in treatment with TMP was noted just a week after treatment, but afterwards declined. Maturation arrest was prominent after 3 weeks in the cases treated with TMP. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Organophosphates / toxicity* | - |
dc.subject.MESH | Organophosphorus Compounds / toxicity* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Spermatogenesis / drug effects* | - |
dc.subject.MESH | Testis / drug effects* | - |
dc.subject.MESH | Testis / physiology | - |
dc.title | Effects of dimethyl methylphosphonate (DMMP) and trimethylphosphate (TMP) on spermatogenesis of rat testis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.identifier.doi | 10.3349/ymj.1994.35.2.198 | - |
dc.contributor.localId | A01710 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 8091797 | - |
dc.contributor.alternativeName | Park, Chan Il | - |
dc.contributor.affiliatedAuthor | 박찬일 | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 208 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.35(2) : 198-208, 1994-06 | - |
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