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간세포암종에서 비외과적 수술 전처치가 암세포 증식능 및 환자의 생존율에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 김호근 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2023-07-12T00:30:46Z | - |
dc.date.available | 2023-07-12T00:30:46Z | - |
dc.date.issued | 1994-12 | - |
dc.identifier.issn | 0379-1149 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195150 | - |
dc.description.abstract | To evaluate the effect of preoperative treatment on proliferative activity and prognosis of the hepatocellular carcinomas(HCCs), fifty-three surgically resected HCCs were studied. Twenty cases were treated preoperatively and thirty-three were not treated before surgery. The proliferation index(PI, % of proliferating cell nuclear antigen positive cells) of the remaining cancer cells following pretreatment was 27.39, which was slightly lower than that of not-pretreated cases(35.41). Although PI was similar among gross types and among histologic grades, tumors of the expanding type and of the histologic grade I revealed distinctly low PI in pretreated cases. Two-year survival rate was not significantly different between pretreated and not-pretreated cases(67.4 vs 52.7). But the differences between gross types(p<0.05) and between histologic grades(p<0.01) were significant. Total necrosis of tumor occurred in five pretreated patients, all of whom were alive during two-year follow-up. Smaller HCCs showed better prognosis(p<0.01). Although PI appeared not correlated well with the two year survival rate, the pretreated HCCs with low PI showed better survival than those with high PI(p<0.05). The results indicate that preoperative modalities induce tumor necrosis, but do not reduce the proliferative activity of tumor cells significantly, and that pretreatment does not affect the long-term prognosis of HCCs except for the occasions of total necrosis of tumor. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한병리학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY (대한병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 간세포암종에서 비외과적 수술 전처치가 암세포 증식능 및 환자의 생존율에 미치는 영향 | - |
dc.title.alternative | The Effect of Preoperative Treatment on Cell Kinetics and Patients Survival in Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 최윤정 | - |
dc.contributor.googleauthor | 김호근 | - |
dc.contributor.googleauthor | 박찬일 | - |
dc.contributor.googleauthor | 정우희 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J02093 | - |
dc.subject.keyword | Preoperative modalities | - |
dc.subject.keyword | Proliferative activity | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Small hepatocellular carcinoma | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Kim, Hogeun | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 정우희 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 605 | - |
dc.citation.endPage | 611 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pathology (대한병리학회지), Vol.28(6) : 605-611, 1994-12 | - |
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