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1-Methyl-r-phenyl-1, 2, 3, 6-tetrahydropyridine이 C57BL/6 마우스의 행동 및 뇌조직 생체내 아민 변동에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2023-07-12T00:19:43Z | - |
dc.date.available | 2023-07-12T00:19:43Z | - |
dc.date.issued | 1994-12 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195022 | - |
dc.description.abstract | The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rodents was investigated by measuring the locomotor activity and the changes of brain biogenic amines in MPTP-treated C57BL/6 mice. The mice showed a typical curved spine posture 24 hours after MPTP treatment. Total locomotor activity was reduced and the ratios of stereotyped activity/total locomotor activity were increased 24 hours after MPTP treatment. However no significant changes were observed 7 days after MPTP treatment. MPTP-induced changes of biogenic amines were evident only in corpus striatum, not in frontal lobe, midbrain and hippocampus; the levels of dopamine, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were reduced by 94%, 76.3% and 60.2% after 24 hours, and 81.9%, 61.3% and 26.1% after 6 days compared to control values respectively. The ratios of DOPAC/dopamine, HVA/dopamine and HVA/DOPAC were increased 24 hours and 7 day after MPTP treatment compared to control valuse in corpus striatum, but the degree of the 7 days was less than the 24 hours. The ratios of 5-HIAA/5-HT were incresed 24 hours and 7 days after MPTP treatment in corpus striatum, but there were no significant changes in the levels of 5-hydroxyindoleacetic acid (5-HIAA) and 5-hydroxtryptamine (5-HT). In conclusion, MPTP produced parkinsonism-like behavioral and biochemical changes in C57BL/ 6 mice. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한신경과학회 | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association(대한신경과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 1-Methyl-r-phenyl-1, 2, 3, 6-tetrahydropyridine이 C57BL/6 마우스의 행동 및 뇌조직 생체내 아민 변동에 미치는 영향 | - |
dc.title.alternative | Changes of Locomolor Activity and Biogenic Amines by 1-Methyl-4-Phenyl-1236-Tetrahydropyridine in C57BL/6 Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | 허지회 | - |
dc.contributor.googleauthor | 김진수 | - |
dc.contributor.googleauthor | 방혜련 | - |
dc.contributor.googleauthor | 김동구 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J01836 | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 593 | - |
dc.citation.endPage | 603 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association (대한신경과학회지), Vol.12(4) : 593-603, 1994-12 | - |
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