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Effect of prophylactic bronchodilator treatment on lung resistance after tracheal intubation
DC Field | Value | Language |
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dc.contributor.author | 길혜금 | - |
dc.date.accessioned | 2023-07-12T00:16:39Z | - |
dc.date.available | 2023-07-12T00:16:39Z | - |
dc.date.issued | 1994-07 | - |
dc.identifier.issn | 0003-3022 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194986 | - |
dc.description.abstract | Background: After induction of anesthesia, lung resistance increases. We hypothesized that prophylactic bronchodilator treatment before tracheal intubation would result in a lower lung resistance after placement of the endotracheal tube. Methods: Forty-two adult patients were randomized to receive one of three inhaled medications 1 h before surgery. All patients first underwent pulmonary function tests. Patients then received either inhaled albuterol (360 micrograms) (n = 12), inhaled ipratropium bromide (72 micrograms) (n = 15) or a placebo inhalation (n = 15). Two, 5, and 15 min after tracheal intubation, lung resistance was measured using the method of von Neergard and Wirtz. Results: Patients who received either bronchodilator had significantly lower lung resistance after intubation than those receiving placebo. At 2 min, lung resistances were 12.7 +/- 1.4 cmH2O.l-1.s-1 (mean +/- SEM) for the placebo group, 6.4 +/- 3.1 cmH2O.l-1.s-1 for the ipratropium-treated group (P < 0.05 vs. placebo), and 7.2 +/- 0.8 cmH2O.l-1.s-1 for the albuterol-treated group (P < 0.05 vs. placebo). The differences in lung resistance persisted through the final measurement at 15 min. Three of fifteen placebo-treated patients developed audible wheezing whereas no patients developed wheezing in either bronchodilator-treated group (P < 0.05 by Fisher's exact test). Although smokers and nonsmokers in the placebo group developed similar resistances after intubation, bronchodilator treatment resulted in lower resistance in nonsmokers than in smokers (P < 0.05). Conclusions: Prophylactic treatment with either an inhaled beta 2-adrenergic agonist or an inhaled cholinergic antagonist produced lower lung resistance after intubation when compared with an inhaled placebo medication. The effect was more pronounced in nonsmokers than in smokers. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANESTHESIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Administration, Inhalation | - |
dc.subject.MESH | Airway Resistance / drug effects* | - |
dc.subject.MESH | Albuterol / adverse effects | - |
dc.subject.MESH | Albuterol / therapeutic use | - |
dc.subject.MESH | Anesthesia / methods | - |
dc.subject.MESH | Bronchoconstrictor Agents / therapeutic use* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intubation, Intratracheal / adverse effects* | - |
dc.subject.MESH | Ipratropium / therapeutic use | - |
dc.subject.MESH | Isoflurane | - |
dc.subject.MESH | Laryngeal Nerves / physiology | - |
dc.subject.MESH | Lung / drug effects* | - |
dc.subject.MESH | Lung / physiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Parasympathetic Nervous System / drug effects | - |
dc.subject.MESH | Parasympathetic Nervous System / physiology | - |
dc.subject.MESH | Respiratory Function Tests | - |
dc.subject.MESH | Tidal Volume | - |
dc.subject.MESH | Trachea / innervation | - |
dc.title | Effect of prophylactic bronchodilator treatment on lung resistance after tracheal intubation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Hae-Keum Kil | - |
dc.contributor.googleauthor | Alec Rooke | - |
dc.contributor.googleauthor | Margaret A. Ryan-Dykes | - |
dc.contributor.googleauthor | Michael J. Bishop | - |
dc.contributor.localId | A00283 | - |
dc.relation.journalcode | J00146 | - |
dc.identifier.eissn | 1528-1175 | - |
dc.identifier.pmid | 8042809 | - |
dc.identifier.url | https://pubs.asahq.org/anesthesiology/article/81/1/43/42058/Effect-of-Prophylactic-Bronchodilator-Treatment-on | - |
dc.contributor.alternativeName | Kil, Hae Keum | - |
dc.contributor.affiliatedAuthor | 길혜금 | - |
dc.citation.volume | 81 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 43 | - |
dc.citation.endPage | 48 | - |
dc.identifier.bibliographicCitation | ANESTHESIOLOGY, Vol.81(1) : 43-48, 1994-07 | - |
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