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Methotrexate 복용에 의한 만성 활동성 간염 -2예 보고
DC Field | Value | Language |
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dc.contributor.author | 박영년 | - |
dc.contributor.author | 박찬일 | - |
dc.date.accessioned | 2023-07-12T00:09:07Z | - |
dc.date.available | 2023-07-12T00:09:07Z | - |
dc.date.issued | 1994-04 | - |
dc.identifier.issn | 0379-1149 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194897 | - |
dc.description.abstract | Although methotrexate(MTX) has been known to have many side effects, especially toxicity on the hemopoietic cells and the liver, it has been used as a potent anticancer drug and for the treatment of psoriasis or rheumatoid arthritis. The severity of hepatotoxicity varies from mild fatty change to chronic active hepatitis(CAH) and cirrhosis. We experienced two cases of MTXinduced CAH in patients with psoriasis, which prompted us to report in view of the absence of biopsy proven MTX hepatotoxicity in the Korean literature. Microscopically, the liver showed a distorted lobular architecture with portal fibrous expansion, piecemeal necrosis and bridging necrosis/fibrosis. The hepatic lobules revealed fatty changes of hepatocyte, focal hepatocytolysis, delicate collagen deposits along the space of Disse and the characteristically marked polyploid nuclear change of hepatocytes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한병리학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY (대한병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Methotrexate 복용에 의한 만성 활동성 간염 -2예 보고 | - |
dc.title.alternative | Methotrexate Induced Chronic Active Hepatitis -A report of two cases - | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 한지영 | - |
dc.contributor.googleauthor | 박영년 | - |
dc.contributor.googleauthor | 박찬일 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01710 | - |
dc.relation.journalcode | J02093 | - |
dc.subject.keyword | Methotrexate | - |
dc.subject.keyword | Hepatotoxicity | - |
dc.subject.keyword | Chronic active hepatitis | - |
dc.subject.keyword | Cirrhosis | - |
dc.subject.keyword | Psoriasis | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | 박영년 | - |
dc.contributor.affiliatedAuthor | 박찬일 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 168 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pathology (대한병리학회지), Vol.28(2) : 168-172, 1994-04 | - |
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