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Efficacy of polyadenylic.polyuridylic acid in the treatment of chronic active hepatitis B
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.date.accessioned | 2023-07-12T00:08:58Z | - |
dc.date.available | 2023-07-12T00:08:58Z | - |
dc.date.issued | 1994-03 | - |
dc.identifier.issn | 0192-0561 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194895 | - |
dc.description.abstract | In order to assess whether polyadenylic.polyuridylic acid [poly(A).poly(U)] can be used as a new therapeutic agent for the treatment of chronic hepatitis B, 19 patients with histologically proven chronic active hepatitis B were injected intravenously with 100-150 mg of poly(A).poly(U) weekly for six weeks. Changes in alanine aminotransferase (ALT) levels, 2',5'-oligoadenylate synthetase (2'.5'-AS) activities and HBV markers were sequentially checked during and after treatments. Serum ALT levels were decreased gradually and 2'.5'-AS activities were significantly increased after initiation of poly(A).poly(U) injections. At the end of this trial (24th week) we have observed the normalizations of elevated ALT levels in 14 (73.7%), negative conversion of HBeAg in 11 (57.9%) and loss of HBV-DNA in 12 out of 19 patients (63.1%). Complete responses which had both normalization of ALT levels and negative conversion of HBeAg were noted in 11 patients (57.9%) and partial responses showing either normalization of ALT levels or negative conversion of HBeAg alone were in four out of 19 patients (21.1%). No notable adverse effects were observed during the treatments and follow-up period. It can be concluded that poly(A).poly(U) seems to be effective in the treatment of chronic active hepatitis B and has an advantage of being free of significant side effects. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | 2',5'-Oligoadenylate Synthetase / blood | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alanine Transaminase / blood | - |
dc.subject.MESH | Biomarkers / blood | - |
dc.subject.MESH | DNA, Viral / blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B / blood | - |
dc.subject.MESH | Hepatitis B / drug therapy* | - |
dc.subject.MESH | Hepatitis B e Antigens / blood | - |
dc.subject.MESH | Hepatitis B virus / isolation & purification | - |
dc.subject.MESH | Hepatitis, Chronic / blood | - |
dc.subject.MESH | Hepatitis, Chronic / drug therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Poly A-U / therapeutic use* | - |
dc.title | Efficacy of polyadenylic.polyuridylic acid in the treatment of chronic active hepatitis B | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | K B Hahm | - |
dc.contributor.googleauthor | K Y Han | - |
dc.contributor.googleauthor | W H Kim | - |
dc.contributor.googleauthor | D S Yim | - |
dc.contributor.googleauthor | C Y Chon | - |
dc.contributor.googleauthor | Y M Moon | - |
dc.contributor.googleauthor | J K Kang | - |
dc.contributor.googleauthor | I S Park | - |
dc.contributor.googleauthor | J K Youn | - |
dc.contributor.googleauthor | E Deschamps de Paillette | - |
dc.identifier.doi | 10.1016/0192-0561(94)90015-9 | - |
dc.contributor.localId | A00774 | - |
dc.relation.journalcode | J03827 | - |
dc.identifier.pmid | 8206687 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/0192056194900159 | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | 김원호 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 225 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, Vol.16(3) : 217-225, 1994-03 | - |
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