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Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies
DC Field | Value | Language |
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dc.contributor.author | 임정은 | - |
dc.date.accessioned | 2023-07-06T06:22:43Z | - |
dc.date.available | 2023-07-06T06:22:43Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194852 | - |
dc.description.abstract | Purpose: This meta-analysis investigated the association between the risk of breast cancer and hormone replacement therapy (HRT). Various stratified analyses were performed according to race (Asian/Westerner), HRT type [all hormone therapies, estrogen-only therapy (ET), or combined estrogen-progestin therapy (EPT)], histological breast cancer type (ductal/lobular/mixed ductal-lobular), and estrogen receptor status (ER-positive/ER-negative). Methods: A literature search was performed using Pubmed, Embase, and KoreaMed. Twenty-five epidemiological studies including 23 cohort studies and two randomized controlled trials were included in this meta-analysis. Results: Using a random-effects model, HRT use was found to be positively associated with the risk of breast cancer with a pooled hazard ratio (HR) of 1.33 [95% confidence interval (CI) 1.24, 1.44]. Compared with ET, EPT was more strongly associated with breast cancer risk. EPT was associated with both ductal and lobular breast cancer risks [for ductal breast cancer, HR = 1.51 (95% CI 1.28, 1.78); for lobular breast cancer, HR = 1.38 (95% CI 1.20, 1.60)]. According to ER status, all HRTs were associated with the risk of ER-positive breast cancer, but not with that of ER-negative breast cancer. Conclusions: Asian HRT users had a higher risk of breast cancer than western HRT users. Both ET and EPT were significantly associated with the risk of all breast cancer histological types and ER-positive breast cancer. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.relation.isPartOf | Breast cancer research and treatment | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers, Tumor | - |
dc.subject.MESH | Breast Neoplasms / epidemiology* | - |
dc.subject.MESH | Breast Neoplasms / etiology* | - |
dc.subject.MESH | Breast Neoplasms / pathology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hormone Replacement Therapy / adverse effects* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Postmenopause | - |
dc.subject.MESH | Randomized Controlled Trials as Topic | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Sohyun Kim | - |
dc.contributor.googleauthor | Yeonsook Ko | - |
dc.contributor.googleauthor | Hwa Jeong Lee | - |
dc.contributor.googleauthor | Jung-Eun Lim | - |
dc.identifier.doi | 10.1007/s10549-018-4782-2 | - |
dc.contributor.localId | A05399 | - |
dc.identifier.pmid | 29713854 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s10549-018-4782-2 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Hormone replacement therapy | - |
dc.subject.keyword | Menopausal hormone therapy | - |
dc.subject.keyword | Meta-analysis. | - |
dc.contributor.alternativeName | Lim, Jung-eun | - |
dc.contributor.affiliatedAuthor | 임정은 | - |
dc.citation.volume | 170 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 667 | - |
dc.citation.endPage | 675 | - |
dc.identifier.bibliographicCitation | Breast cancer research and treatment, Vol.170(3) : 667-675, 2018-08 | - |
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