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Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 주만기 | - |
dc.date.accessioned | 2023-06-14T08:13:15Z | - |
dc.date.available | 2023-06-14T08:13:15Z | - |
dc.date.issued | 2022-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194817 | - |
dc.description.abstract | Introduction: This prospective multicenter study aimed at investigating the safety and metabolic advantages of steroid withdrawal (SW) therapy in kidney transplant recipients with tacrolimus-mycophenolate mofetil-based immunosuppression. Methods: We analyzed 179 recipients who received kidney transplantation from March 2016 and September 2018. In 179 recipients, 114 patients maintained an immunosuppressive regimen including steroids (steroid continuation [SC] group). The remaining 65 patients were determined to withdraw steroid therapy after 6 months posttransplant (SW group). Metabolic parameters and graft functions of the two groups were evaluated. Results: The estimated glomerular filtration rates at 12 months posttransplant were 67.29 ± 20.29 ml/min/1.73 m2 in SC group and 73.72 ± 17.57 ml/min/1.73 m2 in SW group (p < .001). The acute rejection occurred to four recipients in the SC group (3.5%) and no acute rejection occurred to SW group recipients during the 6-2 months posttransplant period. Oral glucose tolerance tests revealed that recipients in the SW group were more improved in glucose metabolism than the SC group during 6-12 months posttransplant. In addition, cholesterol levels and blood pressure decreased after the withdrawal of steroids in the SW group. Conclusion: In conclusion, a 6-month withdrawal of steroids in recipients with low immunological risk and stable graft function can be safely conducted and result in improvement of metabolic profiles. Stable recipients without biopsy-proven acute rejection and proteinuria can safely withdraw from steroids out of a maintenance immunosuppressive regimen 6-months posttransplant. A long-term follow-up study is needed to verify our results. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | John Wiley and Sons Ltd | - |
dc.relation.isPartOf | IMMUNITY INFLAMMATION AND DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Graft Rejection / drug therapy | - |
dc.subject.MESH | Graft Rejection / prevention & control | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Kidney Transplantation* / methods | - |
dc.subject.MESH | Mycophenolic Acid | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Steroids / adverse effects | - |
dc.title | Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jun B Bang | - |
dc.contributor.googleauthor | Chang-Kwon Oh | - |
dc.contributor.googleauthor | Yu S Kim | - |
dc.contributor.googleauthor | Sung H Kim | - |
dc.contributor.googleauthor | Hee C Yu | - |
dc.contributor.googleauthor | Chan-Duck Kim | - |
dc.contributor.googleauthor | Man Ki Ju | - |
dc.contributor.googleauthor | Byung J So | - |
dc.contributor.googleauthor | Sang Ho Lee | - |
dc.contributor.googleauthor | Sang Y Han | - |
dc.contributor.googleauthor | Cheol W Jung | - |
dc.contributor.googleauthor | Joong K Kim | - |
dc.contributor.googleauthor | Hyung J Ahn | - |
dc.contributor.googleauthor | Su H Lee | - |
dc.contributor.googleauthor | Ja Y Jeon | - |
dc.identifier.doi | 10.1002/iid3.576 | - |
dc.contributor.localId | A03949 | - |
dc.relation.journalcode | J03416 | - |
dc.identifier.eissn | 2050-4527 | - |
dc.identifier.pmid | 34913271 | - |
dc.subject.keyword | cholesterol | - |
dc.subject.keyword | glucose tolerance test | - |
dc.subject.keyword | kidney transplantation | - |
dc.subject.keyword | steroids | - |
dc.contributor.alternativeName | Joo, Man Ki | - |
dc.contributor.affiliatedAuthor | 주만기 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e576 | - |
dc.identifier.bibliographicCitation | IMMUNITY INFLAMMATION AND DISEASE, Vol.10(3) : e576, 2022-03 | - |
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