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Safety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study

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dc.contributor.author주만기-
dc.date.accessioned2023-06-14T08:13:15Z-
dc.date.available2023-06-14T08:13:15Z-
dc.date.issued2022-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/194817-
dc.description.abstractIntroduction: This prospective multicenter study aimed at investigating the safety and metabolic advantages of steroid withdrawal (SW) therapy in kidney transplant recipients with tacrolimus-mycophenolate mofetil-based immunosuppression. Methods: We analyzed 179 recipients who received kidney transplantation from March 2016 and September 2018. In 179 recipients, 114 patients maintained an immunosuppressive regimen including steroids (steroid continuation [SC] group). The remaining 65 patients were determined to withdraw steroid therapy after 6 months posttransplant (SW group). Metabolic parameters and graft functions of the two groups were evaluated. Results: The estimated glomerular filtration rates at 12 months posttransplant were 67.29 ± 20.29 ml/min/1.73 m2 in SC group and 73.72 ± 17.57 ml/min/1.73 m2 in SW group (p < .001). The acute rejection occurred to four recipients in the SC group (3.5%) and no acute rejection occurred to SW group recipients during the 6-2 months posttransplant period. Oral glucose tolerance tests revealed that recipients in the SW group were more improved in glucose metabolism than the SC group during 6-12 months posttransplant. In addition, cholesterol levels and blood pressure decreased after the withdrawal of steroids in the SW group. Conclusion: In conclusion, a 6-month withdrawal of steroids in recipients with low immunological risk and stable graft function can be safely conducted and result in improvement of metabolic profiles. Stable recipients without biopsy-proven acute rejection and proteinuria can safely withdraw from steroids out of a maintenance immunosuppressive regimen 6-months posttransplant. A long-term follow-up study is needed to verify our results.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJohn Wiley and Sons Ltd-
dc.relation.isPartOfIMMUNITY INFLAMMATION AND DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHGraft Rejection / drug therapy-
dc.subject.MESHGraft Rejection / prevention & control-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation* / adverse effects-
dc.subject.MESHKidney Transplantation* / methods-
dc.subject.MESHMycophenolic Acid-
dc.subject.MESHProspective Studies-
dc.subject.MESHSteroids / adverse effects-
dc.titleSafety and metabolic advantages of steroid withdrawal after 6 months posttransplant in de novo kidney transplantation: A 1-year prospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJun B Bang-
dc.contributor.googleauthorChang-Kwon Oh-
dc.contributor.googleauthorYu S Kim-
dc.contributor.googleauthorSung H Kim-
dc.contributor.googleauthorHee C Yu-
dc.contributor.googleauthorChan-Duck Kim-
dc.contributor.googleauthorMan Ki Ju-
dc.contributor.googleauthorByung J So-
dc.contributor.googleauthorSang Ho Lee-
dc.contributor.googleauthorSang Y Han-
dc.contributor.googleauthorCheol W Jung-
dc.contributor.googleauthorJoong K Kim-
dc.contributor.googleauthorHyung J Ahn-
dc.contributor.googleauthorSu H Lee-
dc.contributor.googleauthorJa Y Jeon-
dc.identifier.doi10.1002/iid3.576-
dc.contributor.localIdA03949-
dc.relation.journalcodeJ03416-
dc.identifier.eissn2050-4527-
dc.identifier.pmid34913271-
dc.subject.keywordcholesterol-
dc.subject.keywordglucose tolerance test-
dc.subject.keywordkidney transplantation-
dc.subject.keywordsteroids-
dc.contributor.alternativeNameJoo, Man Ki-
dc.contributor.affiliatedAuthor주만기-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPagee576-
dc.identifier.bibliographicCitationIMMUNITY INFLAMMATION AND DISEASE, Vol.10(3) : e576, 2022-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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