Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan; Cassandra N Spracklen; Weihua Zhang; Maggie C Y Ng; Lauren E Petty; Hidetoshi Kitajima; Grace Z Yu; Sina Rüeger; Leo Speidel; Young Jin Kim; Momoko Horikoshi; Josep M Mercader; Daniel Taliun; Sanghoon Moon; Soo-Heon Kwak; Neil R Robertson; Nigel W Rayner; Marie Loh; Bong-Jo Kim; Joshua Chiou; Irene Miguel-Escalada; Pietro Della Briotta Parolo; Kuang Lin; Fiona Bragg; Michael H Preuss; Fumihiko Takeuchi; Jana Nano; Xiuqing Guo; Amel Lamri; Masahiro Nakatochi; Robert A Scott; Jung-Jin Lee; Alicia Huerta-Chagoya; Mariaelisa Graff; Jin-Fang Chai; Esteban J Parra; Jie Yao; Lawrence F Bielak; Yasuharu Tabara; Yang Hai; Valgerdur Steinthorsdottir; James P Cook; Mart Kals; Niels Grarup; Ellen M Schmidt; Ian Pan; Tamar Sofer; Matthias Wuttke; Chloe Sarnowski; Christian Gieger; Darryl Nousome; Stella Trompet; Jirong Long; Meng Sun; Lin Tong; Wei-Min Chen; Meraj Ahmad; Raymond Noordam; Victor J Y Lim; Claudia H T Tam; Yoonjung Yoonie Joo; Chien-Hsiun Chen; Laura M Raffield; Cécile Lecoeur; Bram Peter Prins; Aude Nicolas; Lisa R Yanek; Guanjie Chen; Richard A Jensen; Salman Tajuddin; Edmond K Kabagambe; Ping An; Anny H Xiang; Hyeok Sun Choi; Brian E Cade; Jingyi Tan; Jack Flanagan; Fernando Abaitua; Linda S Adair; Adebowale Adeyemo; Carlos A Aguilar-Salinas; Masato Akiyama; Sonia S Anand; Alain Bertoni; Zheng Bian; Jette Bork-Jensen; Ivan Brandslund; Jennifer A Brody; Chad M Brummett; Thomas A Buchanan; Mickaël Canouil; Juliana C N Chan; Li-Ching Chang; Miao-Li Chee; Ji Chen; Shyh-Huei Chen; Yuan-Tsong Chen; Zhengming Chen; Lee-Ming Chuang; Mary Cushman; Swapan K Das; H Janaka de Silva; George Dedoussis; Latchezar Dimitrov; Ayo P Doumatey; Shufa Du; Qing Duan; Kai-Uwe Eckardt; Leslie S Emery; Daniel S Evans; Michele K Evans; Krista Fischer; James S Floyd; Ian Ford; Myriam Fornage; Oscar H Franco; Timothy M Frayling; Barry I Freedman; Christian Fuchsberger; Pauline Genter; Hertzel C Gerstein; Vilmantas Giedraitis; Clicerio González-Villalpando; Maria Elena González-Villalpando; Mark O Goodarzi; Penny Gordon-Larsen; David Gorkin; Myron Gross; Yu Guo; Sophie Hackinger; Sohee Han; Andrew T Hattersley; Christian Herder; Annie-Green Howard; Willa Hsueh; Mengna Huang; Wei Huang; Yi-Jen Hung; Mi Yeong Hwang; Chii-Min Hwu; Sahoko Ichihara; Mohammad Arfan Ikram; Martin Ingelsson; Md Tariqul Islam; Masato Isono; Hye-Mi Jang; Farzana Jasmine; Guozhi Jiang; Jost B Jonas; Marit E Jørgensen; Torben Jørgensen; Yoichiro Kamatani; Fouad R Kandeel; Anuradhani Kasturiratne; Tomohiro Katsuya; Varinderpal Kaur; Takahisa Kawaguchi; Jacob M Keaton; Abel N Kho; Chiea-Chuen Khor; Muhammad G Kibriya; Duk-Hwan Kim; Katsuhiko Kohara; Jennifer Kriebel; Florian Kronenberg; Johanna Kuusisto; Kristi Läll; Leslie A Lange; Myung-Shik Lee; Nanette R Lee; Aaron Leong; Liming Li; Yun Li; Ruifang Li-Gao; Symen Ligthart; Cecilia M Lindgren; Allan Linneberg; Ching-Ti Liu; Jianjun Liu; Adam E Locke; Tin Louie; Jian'an Luan; Andrea O Luk; Xi Luo; Jun Lv; Valeriya Lyssenko; Vasiliki Mamakou; K Radha Mani; Thomas Meitinger; Andres Metspalu; Andrew D Morris; Girish N Nadkarni; Jerry L Nadler; Michael A Nalls; Uma Nayak; Suraj S Nongmaithem; Ioanna Ntalla; Yukinori Okada; Lorena Orozco; Sanjay R Patel; Mark A Pereira; Annette Peters; Fraser J Pirie; Bianca Porneala; Gauri Prasad; Sebastian Preissl; Laura J Rasmussen-Torvik; Alexander P Reiner; Michael Roden; Rebecca Rohde; Kathryn Roll; Charumathi Sabanayagam; Maike Sander; Kevin Sandow; Naveed Sattar; Sebastian Schönherr; Claudia Schurmann; Mohammad Shahriar; Jinxiu Shi; Dong Mun Shin; Daniel Shriner; Jennifer A Smith; Wing Yee So; Alena Stančáková; Adrienne M Stilp; Konstantin Strauch; Ken Suzuki; Atsushi Takahashi; Kent D Taylor; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Brian Tomlinson; Jason M Torres; Fuu-Jen Tsai; Jaakko Tuomilehto; Teresa Tusie-Luna; Miriam S Udler; Adan Valladares-Salgado; Rob M van Dam; Jan B van Klinken; Rohit Varma; Marijana Vujkovic; Niels Wacher-Rodarte; Eleanor Wheeler; Eric A Whitsel; Ananda R Wickremasinghe; Ko Willems van Dijk; Daniel R Witte; Chittaranjan S Yajnik; Ken Yamamoto; Toshimasa Yamauchi; Loïc Yengo; Kyungheon Yoon; Canqing Yu; Jian-Min Yuan; Salim Yusuf; Liang Zhang; Wei Zheng; FinnGen; eMERGE Consortium; Leslie J Raffel; Michiya Igase; Eli Ipp; Susan Redline; Yoon Shin Cho; Lars Lind; Michael A Province; Craig L Hanis; Patricia A Peyser; Erik Ingelsson; Alan B Zonderman; Bruce M Psaty; Ya-Xing Wang; Charles N Rotimi; Diane M Becker; Fumihiko Matsuda; Yongmei Liu; Eleftheria Zeggini; Mitsuhiro Yokota; Stephen S Rich; Charles Kooperberg; James S Pankow; James C Engert; Yii-Der Ida Chen; Philippe Froguel; James G Wilson; Wayne H H Sheu; Sharon L R Kardia; Jer-Yuarn Wu; M Geoffrey Hayes; Ronald C W Ma; Tien-Yin Wong; Leif Groop; Dennis O Mook-Kanamori; Giriraj R Chandak; Francis S Collins; Dwaipayan Bharadwaj; Guillaume Paré; Michèle M Sale; Habibul Ahsan; Ayesha A Motala; Xiao-Ou Shu; Kyong-Soo Park; J Wouter Jukema; Miguel Cruz; Roberta McKean-Cowdin; Harald Grallert; Ching-Yu Cheng; Erwin P Bottinger; Abbas Dehghan; E-Shyong Tai; Josée Dupuis; Norihiro Kato; Markku Laakso; Anna Köttgen; Woon-Puay Koh; Colin N A Palmer; Simin Liu; Goncalo Abecasis; Jaspal S Kooner; Ruth J F Loos; Kari E North; Christopher A Haiman; Jose C Florez; Danish Saleheen; Torben Hansen; Oluf Pedersen; Reedik Mägi; Claudia Langenberg; Nicholas J Wareham; Shiro Maeda; Takashi Kadowaki; Juyoung Lee; Iona Y Millwood; Robin G Walters; Kari Stefansson; Simon R Myers; Jorge Ferrer; Kyle J Gaulton; James B Meigs; Karen L Mohlke; Anna L Gloyn; Donald W Bowden; Jennifer E Below 8, John C Chambers; Xueling Sim; Michael Boehnke; Jerome I Rotter; Mark I McCarthy; Andrew P Morris

doi:10.1038/s41588-022-01058-3

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Authors: Anubha Mahajan ; Cassandra N Spracklen ; Weihua Zhang ; Maggie C Y Ng ; Lauren E Petty ; Hidetoshi Kitajima ; Grace Z Yu ; Sina Rüeger ; Leo Speidel ; Young Jin Kim ; Momoko Horikoshi ; Josep M Mercader ; Daniel Taliun ; Sanghoon Moon ; Soo-Heon Kwak ; Neil R Robertson ; Nigel W Rayner ; Marie Loh ; Bong-Jo Kim ; Joshua Chiou ; Irene Miguel-Escalada ; Pietro Della Briotta Parolo ; Kuang Lin ; Fiona Bragg ; Michael H Preuss ; Fumihiko Takeuchi ; Jana Nano ; Xiuqing Guo ; Amel Lamri ; Masahiro Nakatochi ; Robert A Scott ; Jung-Jin Lee ; Alicia Huerta-Chagoya ; Mariaelisa Graff ; Jin-Fang Chai ; Esteban J Parra ; Jie Yao ; Lawrence F Bielak ; Yasuharu Tabara ; Yang Hai ; Valgerdur Steinthorsdottir ; James P Cook ; Mart Kals ; Niels Grarup ; Ellen M Schmidt ; Ian Pan ; Tamar Sofer ; Matthias Wuttke ; Chloe Sarnowski ; Christian Gieger ; Darryl Nousome ; Stella Trompet ; Jirong Long ; Meng Sun ; Lin Tong ; Wei-Min Chen ; Meraj Ahmad ; Raymond Noordam ; Victor J Y Lim ; Claudia H T Tam ; Yoonjung Yoonie Joo ; Chien-Hsiun Chen ; Laura M Raffield ; Cécile Lecoeur ; Bram Peter Prins ; Aude Nicolas ; Lisa R Yanek ; Guanjie Chen ; Richard A Jensen ; Salman Tajuddin ; Edmond K Kabagambe ; Ping An ; Anny H Xiang ; Hyeok Sun Choi ; Brian E Cade ; Jingyi Tan ; Jack Flanagan ; Fernando Abaitua ; Linda S Adair ; Adebowale Adeyemo ; Carlos A Aguilar-Salinas ; Masato Akiyama ; Sonia S Anand ; Alain Bertoni ; Zheng Bian ; Jette Bork-Jensen ; Ivan Brandslund ; Jennifer A Brody ; Chad M Brummett ; Thomas A Buchanan ; Mickaël Canouil ; Juliana C N Chan ; Li-Ching Chang ; Miao-Li Chee ; Ji Chen ; Shyh-Huei Chen ; Yuan-Tsong Chen ; Zhengming Chen ; Lee-Ming Chuang ; Mary Cushman ; Swapan K Das ; H Janaka de Silva ; George Dedoussis ; Latchezar Dimitrov ; Ayo P Doumatey ; Shufa Du ; Qing Duan ; Kai-Uwe Eckardt ; Leslie S Emery ; Daniel S Evans ; Michele K Evans ; Krista Fischer ; James S Floyd ; Ian Ford ; Myriam Fornage ; Oscar H Franco ; Timothy M Frayling ; Barry I Freedman ; Christian Fuchsberger ; Pauline Genter ; Hertzel C Gerstein ; Vilmantas Giedraitis ; Clicerio González-Villalpando ; Maria Elena González-Villalpando ; Mark O Goodarzi ; Penny Gordon-Larsen ; David Gorkin ; Myron Gross ; Yu Guo ; Sophie Hackinger ; Sohee Han ; Andrew T Hattersley ; Christian Herder ; Annie-Green Howard ; Willa Hsueh ; Mengna Huang ; Wei Huang ; Yi-Jen Hung ; Mi Yeong Hwang ; Chii-Min Hwu ; Sahoko Ichihara ; Mohammad Arfan Ikram ; Martin Ingelsson ; Md Tariqul Islam ; Masato Isono ; Hye-Mi Jang ; Farzana Jasmine ; Guozhi Jiang ; Jost B Jonas ; Marit E Jørgensen ; Torben Jørgensen ; Yoichiro Kamatani ; Fouad R Kandeel ; Anuradhani Kasturiratne ; Tomohiro Katsuya ; Varinderpal Kaur ; Takahisa Kawaguchi ; Jacob M Keaton ; Abel N Kho ; Chiea-Chuen Khor ; Muhammad G Kibriya ; Duk-Hwan Kim ; Katsuhiko Kohara ; Jennifer Kriebel ; Florian Kronenberg ; Johanna Kuusisto ; Kristi Läll ; Leslie A Lange ; Myung-Shik Lee ; Nanette R Lee ; Aaron Leong ; Liming Li ; Yun Li ; Ruifang Li-Gao ; Symen Ligthart ; Cecilia M Lindgren ; Allan Linneberg ; Ching-Ti Liu ; Jianjun Liu ; Adam E Locke ; Tin Louie ; Jian'an Luan ; Andrea O Luk ; Xi Luo ; Jun Lv ; Valeriya Lyssenko ; Vasiliki Mamakou ; K Radha Mani ; Thomas Meitinger ; Andres Metspalu ; Andrew D Morris ; Girish N Nadkarni ; Jerry L Nadler ; Michael A Nalls ; Uma Nayak ; Suraj S Nongmaithem ; Ioanna Ntalla ; Yukinori Okada ; Lorena Orozco ; Sanjay R Patel ; Mark A Pereira ; Annette Peters ; Fraser J Pirie ; Bianca Porneala ; Gauri Prasad ; Sebastian Preissl ; Laura J Rasmussen-Torvik ; Alexander P Reiner ; Michael Roden ; Rebecca Rohde ; Kathryn Roll ; Charumathi Sabanayagam ; Maike Sander ; Kevin Sandow ; Naveed Sattar ; Sebastian Schönherr ; Claudia Schurmann ; Mohammad Shahriar ; Jinxiu Shi ; Dong Mun Shin ; Daniel Shriner ; Jennifer A Smith ; Wing Yee So ; Alena Stančáková ; Adrienne M Stilp ; Konstantin Strauch ; Ken Suzuki ; Atsushi Takahashi ; Kent D Taylor ; Barbara Thorand ; Gudmar Thorleifsson ; Unnur Thorsteinsdottir ; Brian Tomlinson ; Jason M Torres ; Fuu-Jen Tsai ; Jaakko Tuomilehto ; Teresa Tusie-Luna ; Miriam S Udler ; Adan Valladares-Salgado ; Rob M van Dam ; Jan B van Klinken ; Rohit Varma ; Marijana Vujkovic ; Niels Wacher-Rodarte ; Eleanor Wheeler ; Eric A Whitsel ; Ananda R Wickremasinghe ; Ko Willems van Dijk ; Daniel R Witte ; Chittaranjan S Yajnik ; Ken Yamamoto ; Toshimasa Yamauchi ; Loïc Yengo ; Kyungheon Yoon ; Canqing Yu ; Jian-Min Yuan ; Salim Yusuf ; Liang Zhang ; Wei Zheng ; FinnGen ; eMERGE Consortium ; Leslie J Raffel ; Michiya Igase ; Eli Ipp ; Susan Redline ; Yoon Shin Cho ; Lars Lind ; Michael A Province ; Craig L Hanis ; Patricia A Peyser ; Erik Ingelsson ; Alan B Zonderman ; Bruce M Psaty ; Ya-Xing Wang ; Charles N Rotimi ; Diane M Becker ; Fumihiko Matsuda ; Yongmei Liu ; Eleftheria Zeggini ; Mitsuhiro Yokota ; Stephen S Rich ; Charles Kooperberg ; James S Pankow ; James C Engert ; Yii-Der Ida Chen ; Philippe Froguel ; James G Wilson ; Wayne H H Sheu ; Sharon L R Kardia ; Jer-Yuarn Wu ; M Geoffrey Hayes ; Ronald C W Ma ; Tien-Yin Wong ; Leif Groop ; Dennis O Mook-Kanamori ; Giriraj R Chandak ; Francis S Collins ; Dwaipayan Bharadwaj ; Guillaume Paré ; Michèle M Sale ; Habibul Ahsan ; Ayesha A Motala ; Xiao-Ou Shu ; Kyong-Soo Park ; J Wouter Jukema ; Miguel Cruz ; Roberta McKean-Cowdin ; Harald Grallert ; Ching-Yu Cheng ; Erwin P Bottinger ; Abbas Dehghan ; E-Shyong Tai ; Josée Dupuis ; Norihiro Kato ; Markku Laakso ; Anna Köttgen ; Woon-Puay Koh ; Colin N A Palmer ; Simin Liu ; Goncalo Abecasis ; Jaspal S Kooner ; Ruth J F Loos ; Kari E North ; Christopher A Haiman ; Jose C Florez ; Danish Saleheen ; Torben Hansen ; Oluf Pedersen ; Reedik Mägi ; Claudia Langenberg ; Nicholas J Wareham ; Shiro Maeda ; Takashi Kadowaki ; Juyoung Lee ; Iona Y Millwood ; Robin G Walters ; Kari Stefansson ; Simon R Myers ; Jorge Ferrer ; Kyle J Gaulton ; James B Meigs ; Karen L Mohlke ; Anna L Gloyn ; Donald W Bowden ; Jennifer E Below 8, John C Chambers ; Xueling Sim ; Michael Boehnke ; Jerome I Rotter ; Mark I McCarthy ; Andrew P Morris