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Diabetic bone regeneration with nanoceria-tailored scaffolds by recapitulating cellular microenvironment: Activating integrin/TGF-β co-signaling of MSCs while relieving oxidative stress
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dc.contributor.author | 윤동석 | - |
dc.date.accessioned | 2023-06-02T00:47:58Z | - |
dc.date.available | 2023-06-02T00:47:58Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194443 | - |
dc.description.abstract | Regenerating defective bone in patients with diabetes mellitus remains a significant challenge due to high blood glucose level and oxidative stress. Here we aim to tackle this issue by means of a drug- and cell-free scaffolding approach. We found the nanoceria decorated on various types of scaffolds (fibrous or 3D-printed one; named nCe-scaffold) could render a therapeutic surface that can recapitulate the microenvironment: modulating oxidative stress while offering a nanotopological cue to regenerating cells. Mesenchymal stem cells (MSCs) recognized the nanoscale (tens of nm) topology of nCe-scaffolds, presenting highly upregulated curvature-sensing membrane protein, integrin set, and adhesion-related molecules. Osteogenic differentiation and mineralization were further significantly enhanced by the nCe-scaffolds. Of note, the stimulated osteogenic potential was identified to be through integrin-mediated TGF-β co-signaling activation. Such MSC-regulatory effects were proven in vivo by the accelerated bone formation in rat calvarium defect model. The nCe-scaffolds further exhibited profound enzymatic and catalytic potential, leading to effectively scavenging reactive oxygen species in vivo. When implanted in diabetic calvarium defect, nCe-scaffolds significantly enhanced early bone regeneration. We consider the currently-exploited nCe-scaffolds can be a promising drug- and cell-free therapeutic means to treat defective tissues like bone in diabetic conditions. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Regeneration* / drug effects | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cerium / pharmacology | - |
dc.subject.MESH | Cerium / therapeutic use | - |
dc.subject.MESH | Diabetes Mellitus* / metabolism | - |
dc.subject.MESH | Integrins / metabolism | - |
dc.subject.MESH | Mesenchymal Stem Cells* / drug effects | - |
dc.subject.MESH | Mesenchymal Stem Cells* / metabolism | - |
dc.subject.MESH | Osteogenesis | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Tissue Scaffolds* | - |
dc.subject.MESH | Transforming Growth Factor beta / metabolism | - |
dc.title | Diabetic bone regeneration with nanoceria-tailored scaffolds by recapitulating cellular microenvironment: Activating integrin/TGF-β co-signaling of MSCs while relieving oxidative stress | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Rajendra K Singh | - |
dc.contributor.googleauthor | Dong Suk Yoon | - |
dc.contributor.googleauthor | Nandin Mandakhbayar | - |
dc.contributor.googleauthor | Chengji Li | - |
dc.contributor.googleauthor | Amal George Kurian | - |
dc.contributor.googleauthor | Na-Hyun Lee | - |
dc.contributor.googleauthor | Jung-Hwan Lee | - |
dc.contributor.googleauthor | Hae-Won Kim | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121732 | - |
dc.contributor.localId | A02547 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 36031457 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0142961222003726 | - |
dc.subject.keyword | Diabetic bone regeneration | - |
dc.subject.keyword | MSC activation | - |
dc.subject.keyword | Microenvironment recapitulation | - |
dc.subject.keyword | Nanoceria-tailored scaffolds | - |
dc.subject.keyword | ROS scavenging | - |
dc.contributor.alternativeName | Yoon, Dong Suk | - |
dc.contributor.affiliatedAuthor | 윤동석 | - |
dc.citation.volume | 288 | - |
dc.citation.startPage | 121732 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.288 : 121732, 2022-09 | - |
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