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Clinicopathological Characteristics of Advanced Epstein-Barr Virus-associated Gastric Cancer Highlighting Aberrant p53 Expression
DC Field | Value | Language |
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dc.date.accessioned | 2023-06-02T00:45:36Z | - |
dc.date.available | 2023-06-02T00:45:36Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194402 | - |
dc.description.abstract | Background/aim: Epstein-Barr virus (EBV)-associated gastric cancer is a distinct subtype of stomach adenocarcinoma. Although previous studies have investigated its clinicopathological characteristics, there is a lack of research focusing on advanced EBV-associated gastric cancer. In this study, we performed a comprehensive review of advanced EBV-associated gastric cancer cases. Patients and methods: We retrospectively collected 18 consecutive cases of surgically resected advanced EBV-associated gastric cancer. Clinicopathological parameters were investigated using histological review, immunohistochemistry, and a review of the electronic medical records of the hospital. Results: The predominant histological pattern of advanced EBV-associated gastric cancer, according to the Laurén classification, was intestinal-type adenocarcinoma with varying degrees of differentiation. However, focal areas showing conventional gastric carcinoma with a lymphoid stromal pattern were found in all cases except one. In addition to the previously described histological patterns of EBV-associated gastric cancer, one case displayed chronic granulomatous inflammation-like histology with barely identifiable malignant epithelial cells. Another case had a pure signet-ring cell carcinoma component showing nuclear positivity for the EBV-encoded RNA in situ hybridization assay. Remarkably, five out of 18 cases (27.8%) showed aberrant p53 expression on immunostaining, which is known to occur rarely in EBV-associated gastric cancer. All cases with aberrant p53 expression had intestinal-type adenocarcinoma-like components. Conclusion: Advanced EBV-associated gastric cancer had distinct histology and a higher rate of aberrant p53 immunostaining pattern than conventional EBV-associated gastric cancer. Therefore, their biological behavior should be investigated separately. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma* / pathology | - |
dc.subject.MESH | Epstein-Barr Virus Infections* | - |
dc.subject.MESH | Herpesvirus 4, Human / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | RNA | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Stomach Neoplasms* / pathology | - |
dc.subject.MESH | Tumor Suppressor Protein p53 | - |
dc.title | Clinicopathological Characteristics of Advanced Epstein-Barr Virus-associated Gastric Cancer Highlighting Aberrant p53 Expression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Hyeonguk Jang | - |
dc.contributor.googleauthor | An Na Seo | - |
dc.contributor.googleauthor | Moonsik Kim | - |
dc.identifier.doi | 10.21873/anticanres.16002 | - |
dc.relation.journalcode | J00188 | - |
dc.identifier.eissn | 1791-7530 | - |
dc.identifier.pmid | 36191967 | - |
dc.identifier.url | https://ar.iiarjournals.org/content/42/10/4955.long | - |
dc.subject.keyword | Epstein–Barr virus | - |
dc.subject.keyword | advanced gastric cancer | - |
dc.subject.keyword | gastric carcinoma with lymphoid stroma | - |
dc.subject.keyword | p53 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 4955 | - |
dc.citation.endPage | 4962 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, Vol.42(10) : 4955-4962, 2022-10 | - |
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