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Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 최윤진 | - |
dc.date.accessioned | 2023-06-02T00:43:00Z | - |
dc.date.available | 2023-06-02T00:43:00Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194365 | - |
dc.description.abstract | Purpose: There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence. Materials and methods: We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (non-persistent obesity group; persistent obesity group). Results: Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698). Conclusion: Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alcohol Drinking / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mediation Analysis | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity / epidemiology* | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Stomach Neoplasms / epidemiology* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Joo Hyun Lim | - |
dc.contributor.googleauthor | Cheol Min Shin | - |
dc.contributor.googleauthor | Kyung-Do Han | - |
dc.contributor.googleauthor | Seung Woo Lee | - |
dc.contributor.googleauthor | Eun Hyo Jin | - |
dc.contributor.googleauthor | Yoon Jin Choi | - |
dc.contributor.googleauthor | Hyuk Yoon | - |
dc.contributor.googleauthor | Young Soo Park | - |
dc.contributor.googleauthor | Nayoung Kim | - |
dc.contributor.googleauthor | Dong Ho Lee | - |
dc.identifier.doi | 10.4143/crt.2021.130 | - |
dc.contributor.localId | A05984 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 33940785 | - |
dc.subject.keyword | Dose-response relationship | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Stomach neopla는 | - |
dc.contributor.alternativeName | Choi, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 최윤진 | - |
dc.citation.volume | 54 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 207 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.54(1) : 199-207, 2022-01 | - |
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