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Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김형준 | - |
dc.contributor.author | 장향란 | - |
dc.date.accessioned | 2023-05-31T05:50:37Z | - |
dc.date.available | 2023-05-31T05:50:37Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/194282 | - |
dc.description.abstract | Objectives Peroxiredoxins (Prxs) are antioxidant enzymes that can coordinate cell signal transduction via reactive species scavenging or by acting as redox sensors. The mechanism by which Prxs promote cancer invasion and progression is not yet fully understood. This study aims to elucidate the precise mechanism through which Prx type 5 (Prx5) promotes cancer invasion and tumor growth.,Materials and methods We analyzed the Prx5 expression in oral squamous cell carcinoma (OSCC) by using microarray analysis for gene expression profiling. To identify Prx5 function in cancer, lentiviral short hairpin RNA was used for Prx5 depletion, and invasion assay and mouse xenograft were performed.,Results In microarray data obtained from OSCC patients, Prx5 showed higher expression at the tumor margin (TM) compared to the tumor center (TC) of the collective invasion. The depletion of Prx5 in OSCC cells (Prx5(dep)) led to decreased invasion activity. In orthotopic xenograft models, Prx5(dep) cells harbored delimited tumorigenicity compared to wild-type cells as well as the suppression of lymph node metastasis. Prx5(dep) cells showed growth retardation and increased cellular reactive oxygen species (ROS) levels. The growth retardation of Prx5(dep) cells resulted in G1 phase arrest.,Conclusions This study provides evidence that Prx5 removes excess ROS, especially in the TM, contributing to cancer invasion and tumor progression., | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Munksgaard | - |
dc.relation.isPartOf | ORAL DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinoma, Squamous Cell* / genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Growth Disorders | - |
dc.subject.MESH | Head and Neck Neoplasms* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mouth Neoplasms* / genetics | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Peroxiredoxins / genetics | - |
dc.subject.MESH | Peroxiredoxins / metabolism | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | Squamous Cell Carcinoma of Head and Neck | - |
dc.title | Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) | - |
dc.contributor.googleauthor | Min Kyeong Lee | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Hyung Jun Kim | - |
dc.contributor.googleauthor | Young Sun Hwang | - |
dc.identifier.doi | 10.1111/odi.13910 | - |
dc.contributor.localId | A01156 | - |
dc.contributor.localId | A03489 | - |
dc.relation.journalcode | J02438 | - |
dc.identifier.eissn | 1601-0825 | - |
dc.identifier.pmid | 33969595 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/odi.13910 | - |
dc.subject.keyword | cancer invasion | - |
dc.subject.keyword | cell cycle | - |
dc.subject.keyword | oxidative stress | - |
dc.subject.keyword | peroxiredoxin 5 | - |
dc.subject.keyword | tumor growth | - |
dc.contributor.alternativeName | Kim, Hyung Jun | - |
dc.contributor.affiliatedAuthor | 김형준 | - |
dc.contributor.affiliatedAuthor | 장향란 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 423 | - |
dc.citation.endPage | 435 | - |
dc.identifier.bibliographicCitation | ORAL DISEASES, Vol.29(2) : 423-435, 2023-03 | - |
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